| Substance |
Info | Dose |
Warn | Link |
PubMed |
Latest article |
| Curcumin | 📋 | ✍ | ⛔ | | 40491365 | Exploring the Neuroprotective Potential of Polyphenolic Compounds in Mitigating Quinolinic Acid-Induced Neurotoxicity in Alzheimer's Disease |
| Cannabidiol | 📋 | ✍ | ⛔ | | 40431038 | Chemical Profiling of Polyphenolic Fraction of Cannabis sativa L. vr. Kompolti Industrial Inflorescences: Insights into Cannabidiol Neuroprotective Effects in a Cellular Model of Parkinson's Disease |
| Melatonin | 📋 | ✍ | ⛔ | | 40518038 | Melatonin protects dopaminergic neurons in paraquat-induced Parkinson in rats through PI3K/AKT/Nrf2 pathway |
| Vitamin D3 | 📋 | ✍ | ⛔ | | 40532959 | Role of Vitamin D and Omega 3 Fatty Acids in Improving HDL Biogenesis among Multiple Sclerosis Patients via Orchestrating CHROME/APOA1-AS/ABCA1/APOA1 Milieu |
| Ginsenosides | 📋 | ✍ | ⛔ | | 40510292 | Ginsenoside C-K inhibits A? oligomer-induced Alzheimer's disease pathology progression by regulating microglia-neuron interactions |
| Resveratrol | 📋 | ✍ | ⛔ | | 40507855 | Resveratrol Attenuates CSF Markers of Neurodegeneration and Neuroinflammation in Individuals with Alzheimer's Disease |
| EGCG | 📋 | ✍ | ⛔ | | 40404809 | Epigallocatechin-3-gallate binds tandem RNA recognition motifs of TDP-43 and inhibits its aggregation |
| Berberine | 📋 | ✍ | ⛔ | | 40482960 | Berberine's paradox in Neurodegeneration: Therapeutic promise and safety challenges in Parkinson's disease |
| Quercetin | 📋 | ✍ | ⛔ | | 40511293 | Protective effect of the Quercetin on experimental cuprizone-induced multiple sclerosis in male C57BL/6 mice |
| Ginkgo Biloba | 📋 | ✍ | ⛔ | | 40138777 | Ginkgo biloba Extract GBE50 ameliorates cerebrovascular dysfunction and cognitive impairment in a mouse model of Alzheimer's disease |
| CoQ10 | 📋 | ✍ | ⛔ | | 40277120 | The Potential of Coenzyme Q10 in Alzheimer's Disease: Reducing IL-17 Induced Inflammation and Oxidative Stress for Neuroprotection |
| Phytochemicals | 📋 | | | | 40184012 | Exploring bioactive natural products for treating neurodegenerative diseases: a computational network medicine approach targeting the estrogen signaling pathway in amyotrophic lateral sclerosis and Parkinson's disease |
| Luteolin | 📋 | ✍ | ⛔ | | 40541584 | Untargeted metabolomics reveals the mechanisms of luteolin and exercise combination treatment against cognitive impairments in AD mice through modulating autophagy |
| Astaxanthin | 📋 | ✍ | ⛔ | | 40444055 | Neuroprotective effects of astaxanthin in a scopolamine-induced rat model of Alzheimer's disease through antioxidant/anti-inflammatory pathways and opioid/benzodiazepine receptors: attenuation of Nrf2, NF-κB, and interconnected pathways |
| Food | 📋 | | | | 40361641 | Could a Mediterranean Diet Modulate Alzheimer's Disease Progression? The Role of Gut Microbiota and Metabolite Signatures in Neurodegeneration |
| Ginseng | 📋 | ✍ | ⛔ | | 40453349 | Korean black ginseng extract alleviates Alzheimer's disease-related cognitive impairment by activating the Nrf2/HO-1 pathway and suppressing the p38 MAPK/NF-?B/STAT3 pathways and NLRP3 inflammasome via TLR2 and TLR4 modulation |
| Baicalein | 📋 | ✍ | ⛔ | | 40490169 | Therapeutic potential of flavonoids against ?-synuclein aggregation in Parkinson's Disease: Integrative in silico and in vitro analysis |
| Lipoic Acid | 📋 | ✍ | ⛔ | | 40411245 | ALSUntangled #79: alpha-lipoic acid |
| Docosahexaenoic Acid | 📋 | ✍ | ⛔ | | 40316879 | Dual Mechanism of Docosahexaenoic acid (DHA) in Alzheimer's Disease: PAD4 Inhibition and Autophagy Stimulation |
| Vitamin E | 📋 | ✍ | ⛔ | | 40341407 | The role of ferroptosis in Alzheimer's disease: Mechanisms and therapeutic potential (Review) |
| Genistein | 📋 | ✍ | ⛔ | | 39828018 | Genistein: A Promising Ally in Combating Neurodegenerative Disorders |
| Astragalosides | 📋 | ✍ | ⛔ | | 40449268 | Astragaloside IV ameliorates Parkinson's disease by inhibiting TLR4/NF-?B-dependent neuroinflammation |
| Ellagic Acid | 📋 | ✍ | ⛔ | | 40446132 | Clinical and Mechanistic Exploration of Ellagic Acid in Neurodegenerative Diseases: Targeted Neuroprotection Through Cellular and Molecular Mechanisms |
| Medicinal Plants | 📋 | | | | 40034353 | Synergistic activity of nootropic herbs as potent therapeutics for Alzheimer's disease: A cheminformatics, pharmacokinetics, and system pharmacology approach |
| Salidroside | 📋 | | | | 39503755 | Synthesizing network pharmacology, bioinformatics, and in vitro experimental verification to screen candidate targets of Salidroside for mitigating Alzheimer's disease |
| Ginkgolides | 📋 | | | | 40522419 | A Cross-sectional In Vitro Study on the Synergistic Neuroprotective Effects of Phytochemicals Ferulic Acid and Ginkgolide B against Amyloid Beta-induced Oxidative Stress and Modulation of Multifunctional Enzyme APE1/Ref-1 in Human Neuroblastoma SH-SY5Y Cells |
| Vitamin C | 📋 | ✍ | ⛔ | | 40415164 | Association of antioxidants intake in diet and supplements with risk of Alzheimer's disease: a systematic review and dose-response meta-analysis of prospective cohort studies |
| Crocin | 📋 | ✍ | ⛔ | | 40419073 | Crocin drives intestinal microbiota variation in a rat model of Alzheimer's disease by reducing DKK3 expression |
| Icariin | 📋 | ✍ | | | 40403897 | Icariin alleviates cognitive dysfunction by reducing neuroinflammation via the cGAS-STING pathway |
| Saffron | 📋 | ✍ | ⛔ | | 40455336 | Significance feature of saffron on testicular histomorphometry and expression profile of antioxidant enzymes in mice with induced multiple sclerosis: an in-vivo study |
| Omega-3 Fatty Acids | 📋 | ✍ | ⛔ | | 40532959 | Role of Vitamin D and Omega 3 Fatty Acids in Improving HDL Biogenesis among Multiple Sclerosis Patients via Orchestrating CHROME/APOA1-AS/ABCA1/APOA1 Milieu |
| Sulforaphane | 📋 | ✍ | ⛔ | | 39551165 | Sulforaphane suppresses Aβ accumulation and tau hyperphosphorylation in vascular cognitive impairment(VCI) |
| Micronutrients | 📋 | | ⛔ | | 40299221 | Unraveling the Immune Puzzle: Role of Immunomodulation in Alzheimer's Disease |
| Naringenin | 📋 | ✍ | ⛔ | | 40486726 | Promising neuroprotective potential of naringenin against trimethyltin-induced cognitive deficits and hippocampal neurodegeneration in rats |
| TUDCA | 📋 | ✍ | ⛔ | | 39891787 | The effects of ursodeoxycholic acid on Parkinson's disease, a mechanistic review of the recent evidence |
| Ferulic Acid | 📋 | ✍ | ⛔ | | 40522419 | A Cross-sectional In Vitro Study on the Synergistic Neuroprotective Effects of Phytochemicals Ferulic Acid and Ginkgolide B against Amyloid Beta-induced Oxidative Stress and Modulation of Multifunctional Enzyme APE1/Ref-1 in Human Neuroblastoma SH-SY5Y Cells |
| Metformin | 📋 | ✍ | ⛔ | | 40478515 | Low-Dose Intranasal Metformin Exerts Neuroprotective Effects in a Rat Model of Sporadic Alzheimer's Disease |
| Puerarin | 📋 | ✍ | ⛔ | | 39545064 | Combined administration of catalpol, puerarin, gastrodin, and borneol modulates the Tlr4/Myd88/NF-κB signaling pathway and alleviates microglia inflammation in Alzheimer's disease |
| Schisandra | 📋 | ✍ | ⛔ | | 40088743 | Schisandra total lignans ameliorate neuronal ferroptosis in 3xTg-AD mice via regulating NADK/NADPH/GSH pathway |
| Vitamin B12 | 📋 | ✍ | ⛔ | | 39209095 | Management of Alzheimer's disease and related neurotoxic pathologies: Role of thiamine, pyridoxine and cobalamin |
| Acetyl-L-Carnitine | 📋 | ✍ | ⛔ | | 39716786 | Acetyl-L-Carnitine Aids in Preservation of Cholinergic Neurons and Memory in the Drosophila melanogaster Model of Alzheimer's Disease |
| Antioxidants | 📋 | | ⛔ | | 40332186 | Role of Antioxidants in Modulating the Microbiota-Gut-Brain Axis and Their Impact on Neurodegenerative Diseases |
| Apigenin | 📋 | ✍ | ⛔ | | 40215824 | Apigenin enhances Nrf2-induced chaperone-mediated autophagy and mitigates α-synuclein pathology: Implications for Parkinson's disease therapy |
| Fisetin | 📋 | ✍ | ⛔ | | 40475252 | Inhibitory effect of Fisetin against the aggregation process of SOD1 E100K mutant: computer-based drug design as a potential therapeutic for ALS disease |
| Gotu Kola | 📋 | ✍ | ⛔ | | 40034352 | Centella asiatica improves cognitive function and alters the hippocampal metabolome of aged Tg2576 and wild-type mice |
| Hesperidin | 📋 | ✍ | ⛔ | | 40445481 | Neuroprotective Effects of Hesperidin and CK2 Inhibitor DRB on A?1-42-Induced Neurotoxicity in Differentiated SH-SY5Y Cells |
| Rutin | 📋 | ✍ | ⛔ | | 40510902 | Potential of rutin from Rhizophora mucronata leaves as a Inhibitor of Kelch-like ECH-associated protein 1/Nuclear factor erythroid 2 related factor 2 Keap1/Nrf2): An in silico study for Alzheimer's therapy |
| Ashwagandha | 📋 | ✍ | ⛔ | | 40508211 | Preclinical Evidence of Withania somnifera and Cordyceps spp.: Neuroprotective Properties for the Management of Alzheimer's Disease |
| Caffeine | 📋 | ✍ | ⛔ | | 40404275 | The association between lifestyle factors and mortality in Huntington's disease |
| Nobiletin | 📋 | ✍ | | | 38781730 | Nobiletin regulates intracellular Ca2+ levels via IP3R and ameliorates neuroinflammation in Aβ42-induced astrocytes |
| Carvacrol | 📋 | ✍ | ⛔ | | 40465192 | Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulation Guided Discovery of Anethole, Carvacrol, Carnosol, Nicotine, and Paeonol as Potential Therapeutics for Parkinson's Disease |
| Goji Berry | 📋 | ✍ | ⛔ | | 40145961 | Effects of Lycium barbarum polysaccharide on the activation of pathogenic CD4+ T cells in a mouse model of multiple sclerosis |
| Nicotinamide Riboside | 📋 | ✍ | ⛔ | | 39422945 | Supplementation with NAD+ Precursors for Treating Alzheimer's Disease: A Metabolic Approach |
| Polyphenols | 📋 | | | | 40400913 | Polyphenols and miRNA interplay: a novel approach to combat apoptosis and inflammation in Alzheimer's disease |
| Probiotics | 📋 | ✍ | ⛔ | | 40444050 | Chronic administration of prebiotics and probiotics prevent pathophysiological hallmarks of Alzheimer's disease in the cortex of APP/PS1 mice |
| Lycopene | 📋 | ✍ | ⛔ | | 40378674 | Lycopene alleviates cognitive dysfunctions in an Alzheimer's disease rat model via suppressing the oxidative and neuroinflammatory signaling |
| Reishi Mushrooms | 📋 | ✍ | ⛔ | | 40227285 | Polysaccharides from Ganoderma lucidum attenuate cognitive impairment in 5xFAD mice by inhibiting oxidative stress and modulating mitochondrial dynamics via the Nrf2/antioxidative axis activation |
| Piperine | 📋 | ✍ | ⛔ | | 38158101 | Piperine promotes PI3K/AKT/mTOR-mediated gut-brain autophagy to degrade α-Synuclein in Parkinson's disease rats |
| Andrographolide | 📋 | | | | 37571363 | The Effects of Andrographis paniculata (Burm.F.) Wall. Ex Nees and Andrographolide on Neuroinflammation in the Treatment of Neurodegenerative Diseases |
| Coconut Oil | 📋 | | ⛔ | | 38052316 | Coconut oil ameliorates behavioral and biochemical alterations induced by D-GAL/AlCl3 in rats |
| N-Acetyl Cysteine | 📋 | ✍ | ⛔ | | 40510771 | Current trends and future prospects of N-acetylcysteine utilizations in Parkinson's disease: A literature network analysis |
| Rosmarinic Acid | 📋 | ✍ | | | 40183159 | Proteomic Analysis of Substantia Nigra Reveals Molecular Insights Into the Neuroprotection Effect of Rosmarinic Acid Treatment in MPTP-Induced Mouse Model of Parkinson's Disease |
| Thymoquinone | 📋 | | ⛔ | | 40305274 | Evaluation of the Effects of Thymoquinone on RAGE/NOX4 Expressions and Brain Tissue Morphometry in Experimental Alzheimer's Disease Induced by Amyloid Beta 1-42 Peptide |
| Selenium | 📋 | ✍ | ⛔ | | 40341407 | The role of ferroptosis in Alzheimer's disease: Mechanisms and therapeutic potential (Review) |
| Mangiferin | 📋 | | ⛔ | | 40271493 | Natural polyphenol mangiferin delays neuronal cell senescence by inhibiting neuroinflammation mediated by microglial activation |
| Moringa Oleifera | 📋 | ✍ | ⛔ | | 40448817 | Exploring the therapeutic role of Moringa oleifera in neurodegeneration: antioxidant, anti-inflammatory, and neuroprotective mechanisms |
| Flavonoids | 📋 | | ⛔ | | 40426656 | The Role of Selected Flavonoids in Modulating Neuroinflammation in Alzheimer's Disease: Mechanisms and Therapeutic Potential |
| Fucoidan | 📋 | ✍ | ⛔ | | 39521225 | Fucoidan ameliorates rotenone-induced Parkinsonism in mice by regulating the microbiota-gut-brain axis |
| Naringin | 📋 | ✍ | ⛔ | | 40123459 | Co-administration of Naringin and NLRP3 Inhibitor Improves Myelin Repair and Mitigates Oxidative Stress in Cuprizone-Induced Demyelination Model |
| NMN | 📋 | ✍ | ⛔ | | 39422945 | Supplementation with NAD+ Precursors for Treating Alzheimer's Disease: A Metabolic Approach |
| Oleuropein | 📋 | | | | 36774383 | Oleuropein confers neuroprotection against rotenone-induced model of Parkinson's disease via BDNF/CREB/Akt pathway |
| Pomegranate | 📋 | | ⛔ | | 39519499 | In Vitro Assessment of the Neuroprotective Effects of Pomegranate (Punica granatum L.) Polyphenols Against Tau Phosphorylation, Neuroinflammation, and Oxidative Stress |
| Pterostilbene | 📋 | ✍ | ⛔ | | 40291020 | Pterostilbene: A natural neuroprotective stilbene with anti-Alzheimer's disease properties |
| Silymarin | 📋 | ✍ | ⛔ | | 40193019 | Evaluating the Protective Effects of Silymarin Along with a Cholesterol-Supplemented Diet Against Demyelination in an EAE Mouse Model of Multiple Sclerosis: Lipidomic and Inflammatory Aspects |
| Vitamin B9 | 📋 | ✍ | ⛔ | | 38700503 | Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials |
| Boswellic Acid | 📋 | ✍ | ⛔ | | 39487943 | Acetyl 11-Keto Beta-Boswellic Acid Improves Neurological Functions in a Mouse Model of Multiple Sclerosis |
| Chlorogenic Acid | 📋 | ✍ | ⛔ | | 40243772 | Neuroprotective Effects of Cilomilast and Chlorogenic Acid Against Scopolamine-Induced Memory Deficits via Modulation of the cAMP/PKA-CREB-BDNF Pathway |
| Chrysin | 📋 | ✍ | ⛔ | | 39748776 | Therapeutic potential of chrysin in regulation of interleukin-17 signaling in a repeated intranasal amyloid-beta-induced Alzheimer's disease model |
| Cinnamon | 📋 | ✍ | ⛔ | | 37275760 | Effect of insulin and cinnamon extract on spatial memory and gene expression of GLUT1, 3, and 4 in streptozotocin-induced Alzheimer's model in rats |
| Irisin | 📋 | | | | 40427436 | Role and Functions of Irisin: A Perspective on Recent Developments and Neurodegenerative Diseases |
| Olive Polyphenols | 📋 | | | | 39482909 | Alzheimer's Disease May Benefit from Olive Oil Polyphenols: A Systematic Review on Preclinical Evidence Supporting the Effect of Oleocanthal on Amyloid-β Load |
| Anthocyanins | 📋 | ✍ | ⛔ | | 37346934 | Attenuation of amyloid-β-induced mitochondrial dysfunction by active components of anthocyanins in HT22 neuronal cells |
| Bacopa Monnieri | 📋 | ✍ | ⛔ | | 40251199 | Bacopa monnieri phytochemicals as promising BACE1 inhibitors for Alzheimer's disease therapy |
| Citicoline | 📋 | ✍ | ⛔ | | 39143698 | Dysregulation of choline metabolism and therapeutic potential of citicoline in Huntington's disease |
| Fucoxanthin | 📋 | ✍ | ⛔ | | 40272460 | Long-term fucoxanthin treatment prevents cognitive impairments and neuroinflammation via the inhibition of Nogo-A in APP/PS1 transgenic mice |
| Grape Seed extract | 📋 | ✍ | ⛔ | | 39682936 | Exploring the Neuroprotective Effects of Grape Seed Procyanidins on Amyloid-β-Induced Toxicity in Caenorhabditis elegans |
| Olive Oil | 📋 | ✍ | ⛔ | | 39061831 | Neuroprotective Effects of Olive Oil: A Comprehensive Review of Antioxidant Properties |
| Urolithins | 📋 | | | | 40280244 | Urolithin improves α-synuclein aggregation and DNMT1 expression in rotenone model of Parkinson's disease |
| Walnut | 📋 | | ⛔ | | 39683877 | Characterization of Walnut Oil and Evaluation of Its Neuroprotective Effects in an In Vitro Model of Parkinson's Disease |
| Catechins | 📋 | | | | 40172817 | Neuroprotective Effects of Catechins by Differentially Affecting the Binding of Beta-amyloid and Its Aggregates to the Target Cells |
| Echinacoside | 📋 | | | | 40233432 | Integrated bioinformatics and experimental verification to dissect the mechanisms and bioactive ingredients of Radix Rehmanniae in treating multiple sclerosis |
| Hesperetin | 📋 | | | | 38517352 | Natural flavonoid hesperetin blocks amyloid β-protein fibrillogenesis, depolymerizes preformed fibrils and alleviates cytotoxicity caused by amyloids |
| Kaempferol | 📋 | ✍ | ⛔ | | 40174341 | Baicalin and kaempferol alleviates cuprizone-induced demyelination and microglial activation by inhibiting the STAT3 and NF-?B signaling pathways |
| Licorice Root | 📋 | ✍ | ⛔ | | 39757620 | Neuroactive Phytoconstituents of Glycyrrhiza glabra for the Treatment of Alzheimer's Disease |
| Silibinin | 📋 | ✍ | | | 39833635 | Silibinin's role in counteracting neuronal apoptosis and synaptic dysfunction in Alzheimer's disease models |
| Dihydromyricetin | 📋 | ✍ | ⛔ | | 37712262 | [Dihydromyricetin alleviates pyroptosis and necroptosis in mice with MPTP-induced chronic Parkinson's disease by inducing autophagy] |
| Eicosapentaenoic Acid | 📋 | ✍ | ⛔ | | 39490923 | Differential impact of eicosapentaenoic acid and docosahexaenoic acid in an animal model of Alzheimer's disease |
| Hydroxytyrosol | 📋 | | | | 37834398 | The Impact of Hydroxytyrosol on the Metallomic-Profile in an Animal Model of Alzheimer's Disease |
| L-Theanine | 📋 | ✍ | ⛔ | | 40504752 | Therapeutic Role of l-Theanine in Mitigating Cognitive Dysfunction and Neuropathology in Scopolamine-Treated Mice |
| Myricetin | 📋 | | ⛔ | | 40383467 | Mechanism of flavonoid myricetin modulated aggregation in ?-Synuclein and its familial mutants E46K and A30P |
| Paeoniflorin | 📋 | | | | 40332313 | Paeoniflorin Directly Targets ENO1 to Inhibit M1 Polarization of Microglia/Macrophages and Ameliorates EAE Disease |
| Asiatic Acid | 📋 | | | | 40005058 | Oral Asiatic Acid Improves Cognitive Function and Modulates Antioxidant and Mitochondrial Pathways in Female 5xFAD Mice |
| Baicalin | 📋 | ✍ | ⛔ | | 40174341 | Baicalin and kaempferol alleviates cuprizone-induced demyelination and microglial activation by inhibiting the STAT3 and NF-?B signaling pathways |
| Carnosic Acid | 📋 | | | | 36903551 | Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action |
| Carotenoids | 📋 | ✍ | ⛔ | | 39455919 | The relationship between micronutrients and cognitive ability in an elderly population with mild cognitive impairment and Alzheimer's disease: a cross-sectional study |
| Coffee | 📋 | ✍ | ⛔ | | 40286889 | Coffee consumption and risk of multiple sclerosis: A systematic review and meta-analysis |
| Gallic Acid | 📋 | | ⛔ | | 39909215 | Quantification of amyloid-β aggregation inhibitors gallic acid and rosmarinic acid in biological samples by LC-MS/MS |
| Ginger | 📋 | ✍ | ⛔ | | 39829385 | Ginger leaf polyphenols mitigate β-amyloid toxicity via JNK/FOXO pathway activation in Caenorhabditis elegans |
| Senolytics | 📋 | | | | 40196013 | Targeting senescence in Amyotrophic Lateral Sclerosis: senolytic treatment improves neuromuscular function and preserves cortical excitability in a TDP-43Q331K mouse model |
| Zinc | 📋 | ✍ | ⛔ | | 40491365 | Exploring the Neuroprotective Potential of Polyphenolic Compounds in Mitigating Quinolinic Acid-Induced Neurotoxicity in Alzheimer's Disease |
| Cocoa | 📋 | ✍ | ⛔ | | 40158278 | Combining vinpocetine or cocoa with levodopa, Coenzyme Q10 and vitamin B complex mitigates rotenone-induced Parkinson's disease in rats: Impact on Nrf2/HO-1, NF-kB, AMPK/SIRT-1/Beclin-1, AKT/GSK-3?/CREB/BDNF and Apoptotic Pathways |
| Emodin | 📋 | | ⛔ | | 40340509 | Emodin ameliorates dopaminergic neuron loss in the MPP+ induced parkinson's disease model: significant inhibition of ferroptosis by activating UQCRC1 protein |
| Magnesium | 📋 | ✍ | ⛔ | | 39387051 | Neuroprotective effects of magnesium: implications for neuroinflammation and cognitive decline |
| NAD | 📋 | | | | 40320991 | Nicotinamide Adenine Dinucleotide Supplementation Improves Cuprizone-Induced Multiple Sclerosis-Related Behavioral Changes in C57BL/6J Mice |
| Prebiotics | 📋 | ✍ | ⛔ | | 40444050 | Chronic administration of prebiotics and probiotics prevent pathophysiological hallmarks of Alzheimer's disease in the cortex of APP/PS1 mice |
| Rapamycin | 📋 | ✍ | | | 38640155 | Effect and Mechanism of Rapamycin on Cognitive Deficits in Animal Models of Alzheimer's Disease: A Systematic Review and Meta-analysis of Preclinical Studies |
| Salvianolic Acid | 📋 | | | | 40377822 | Salvianolic acid B ameliorates A?42 toxicity in A?42-expressing Drosophila model: behavioral and transcriptomic profiling |
| Skullcap | 📋 | ✍ | ⛔ | | 38645989 | Network Pharmacology and Molecular Docking Identify the Potential Mechanism and Therapeutic Role of Scutellaria baicalensis in Alzheimer's Disease |
| Asiaticoside | 📋 | | | | 38471370 | Asiaticoside exerts neuroprotection through targeting NLRP3 inflammasome activation |
| Astragalus Root | 📋 | ✍ | ⛔ | | 39401575 | Microglia-astrocyte crosstalk is regulated by Astragalus polysaccharides mediated through suppression of Sema4D-PlexinB2 signaling in experimental autoimmune encephalomyelitis |
| Bee Venom | 📋 | ✍ | ⛔ | | 37317907 | Memory Enhancing and Neurogenesis Activity of Honey Bee Venom in the Symptoms of Amnesia: Using Rats with Amnesia-like Alzheimer's Disease as a Model |
| Catalpol | 📋 | | | | 39545064 | Combined administration of catalpol, puerarin, gastrodin, and borneol modulates the Tlr4/Myd88/NF-κB signaling pathway and alleviates microglia inflammation in Alzheimer's disease |
| Cordycepin | 📋 | | | | 40202221 | Exploring Cordycepin as a Neuroprotective Agent in Huntington's Disease: In Vitro and In Vivo Insights |
| Creatine | 📋 | ✍ | ⛔ | | 40395689 | Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition |
| Frankincense | 📋 | ✍ | ⛔ | | 38911256 | Frankincense: A neuronutrient to approach Parkinson's disease treatment |
| Ganoderic Acid | 📋 | | | | 40054827 | The anti-Alzheimer's disease effects of ganoderic acid A by inhibiting ferroptosis-lipid peroxidation via activation of the NRF2/SLC7A11/GPX4 signaling pathway |
| Green Tea Polyphenols | 📋 | ✍ | ⛔ | | 39956389 | Protection of Green Tea Polyphenols against Neurodegenerative Diseases: Evidence and Possible Mechanisms |
| Honokiol | 📋 | | | | 40481059 | Inhibition of levodopa metabolism to dopamine by honokiol short-chain fatty acid derivatives may enhance therapeutic efficacy in Parkinson's disease |
| Icaritin | 📋 | | | | 39931983 | The Role and Molecular Mechanism of Icaritin in the Treatment of Alzheimer's Disease |
| Morin | 📋 | | | | 40372795 | Morin Interacts with ?-Synuclein and Retards Its Fibrillation |
| Aged Garlic | 📋 | ✍ | ⛔ | | 35805955 | Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer's Disease |
| Artemisinin | 📋 | | | | 39795253 | Artemisinin Stimulates Neuronal Cell Viability and Possess a Neuroprotective Effect In Vitro |
| Bilobalide | 📋 | | | | 36037147 | Targeting the differentiation of astrocytes by Bilobalide in the treatment of Parkinson's disease model |
| Dihydroquercetin | 📋 | | | | 38723817 | Dihydroquercetin alleviates dopamine neuron loss via regulating TREM2 activation |
| Ginger extract | 📋 | ✍ | ⛔ | | 40002693 | A Standardized Extract of Zingiber officinale Roscoe Regulates Clinical and Biological Outcomes in Two Different EAE Mouse Models |
| Isoliquiritigenin | 📋 | | | | 40414556 | Isoliquiritigenin attenuated cognitive impairment, cerebral tau phosphorylation and oxidative stress in a streptozotocin-induced mouse model of Alzheimer's disease |
| L-Carnosine | 📋 | ✍ | ⛔ | | 39933073 | Carnosine Mitigates Cognitive Impairment and Dopamine Release in an Okadaic Acid-Induced Zebrafish Model with Alzheimer's Disease-like Symptoms |
| Lutein | 📋 | ✍ | ⛔ | | 39640747 | Lutein improves remyelination by reducing of neuroinflammation in C57BL/6 mouse models of multiple sclerosis |
| Mulberry | 📋 | | ⛔ | | 38612872 | Mulberry Leaf Compounds and Gut Microbiota in Alzheimer's Disease and Diabetes: A Study Using Network Pharmacology, Molecular Dynamics Simulation, and Cellular Assays |
| Mushrooms | 📋 | | ⛔ | | 37569241 | Unveiling the Therapeutic Potentials of Mushroom Bioactive Compounds in Alzheimer's Disease |
| Ollive Leaf extract | 📋 | ✍ | ⛔ | | 39585054 | The Role of Greek Olive Leaf Extract in Patients with Mild Alzheimer's Disease (the GOLDEN Study): A Randomized Controlled Clinical Trial |
| Panax Notoginseng | 📋 | ✍ | ⛔ | | 40232582 | The role of Panax ginseng in neurodegenerative disorders: mechanisms, benefits, and future directions |
| Punicalagin | 📋 | ✍ | ⛔ | | 39374157 | Neuroprotective effects of punicalagin and/or micronized zeolite clinoptilolite on manganese-induced Parkinson's disease in a rat model: Involvement of multiple pathways |
| Schisandrins | 📋 | | | | 40382817 | Schisandrin B ameliorates Alzheimer's disease by suppressing neuronal ferroptosis and ensuing microglia M1 polarization |
| Spikenard | 📋 | ✍ | ⛔ | | 40358168 | Nardostachys jatamansi Extract and Nardosinone Exert Neuroprotective Effects by Suppressing Glucose Metabolic Reprogramming and Modulating T Cell Infiltration |
| Taurine | 📋 | ✍ | ⛔ | | 39674372 | Taurine, an essential amino acid, attenuates rotenone-induced Parkinson's disease in rats by inhibiting alpha-synuclein aggregation and augmenting dopamine release |
| Ursolic Acid | 📋 | ✍ | ⛔ | | 40167825 | Ursolic acid derivatives improved clinical signs of experimental autoimmune encephalomyelitis by modulating central nervous system inflammation |
| Vitamin A | 📋 | ✍ | ⛔ | | 40341393 | Impact of vitamin A on aged people's cognition and Alzheimer's disease progression in an animal model |
| Vitamin B1 | 📋 | ✍ | ⛔ | | 39836750 | Biotin mitigates the development of manganese-induced, Parkinson's disease-related neurotoxicity in Drosophila and human neurons |
| Vitamins | 📋 | | | | 39941101 | Vitamins in the Prevention and Support Therapy of Neurodegenerative Diseases |
| Withanolides | 📋 | | | | 39721456 | The total withanolides from the leaves of Datura stramonium L. Improves Alzheimer's disease pathology by restraining neuroinflammation through NLRP3/IL-1β/IL1R1/TOM 1 pathway |
| Allicin | 📋 | ✍ | ⛔ | | 35805955 | Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer's Disease |
| Bee Propolis | 📋 | ✍ | ⛔ | | 40333577 | Nature's Remedies: Exploring the Potential of Propolis to Alleviate Non-Motor Manifestations of Parkinson's Disease |
| Beta-Sitosterol | 📋 | ✍ | ⛔ | | 39850118 | Dietary supplements for prevention of Alzheimer's disease: In vivo and in silico molecular docking studies |
| Butyrate | 📋 | | ⛔ | | 38694925 | Buty and the beast: the complex role of butyrate in Parkinson's disease |
| Choline | 📋 | ✍ | ⛔ | | 40447055 | Dietary Choline Intake and Risk of Alzheimer's Dementia in Older Adults |
| Eugenol | 📋 | | | | 39410958 | Neuroprotective Potential of Eugenol in Polyglutamine-Mediated Neurodegenerative Disease Using Transgenic Drosophila Model |
| Formononetin | 📋 | | | | 40377696 | Protective effect of formononetin in chronic unpredictable stress (CUS) linked to parkinson disease |
| Garlic | 📋 | ✍ | ⛔ | | 40324650 | Preventive effect of a garlic compound on astrocyte-mediated neuroinflammation in Parkinson's disease |
| Hyperoside | 📋 | | | | 39489478 | Pharmacological activities and therapeutic potential of Hyperoside in the treatment of Alzheimer's and Parkinson's diseases: A systemic review |
| L-Carnitine | 📋 | ✍ | ⛔ | | 39674916 | Carnitine supplementation in progressive supranuclear palsy |
| Lion's Mane Mushrooms | 📋 | ✍ | ⛔ | | 39988819 | Hericium erinaceus: A possible future therapeutic treatment for the prevention and delayed progression of Alzheimer's disease? - A Narrative Review |
| Magnolol | 📋 | | | | 39624588 | Magnolol acts as a neurorestorative agent in an Aβ1?42-induced mouse model of Alzheimer's disease |
| Mangosteen | 📋 | ✍ | ⛔ | | 36552604 | Mangosteen Pericarp Extract Supplementation Boosts Antioxidant Status via Rebuilding Gut Microbiota to Attenuate Motor Deficit in 6-OHDA-Induced Parkinson's Disease |
| Nigella Sativa | 📋 | ✍ | ⛔ | | 29962349 | A Review on Possible Therapeutic Effect of Nigella sativa and Thymoquinone in Neurodegenerative Diseases |
| Pine Bark | 📋 | ✍ | ⛔ | | 36153882 | Pycnogenol® supplementation alleviates symptoms of Parkinson's disease with mild cognitive impairment |
| Spirulina | 📋 | ✍ | ⛔ | | 39565401 | Aqueous extract of Spirulina exerts neuroprotection in an experimental model of Alzheimer sporadic disease in mice induced by Streptozotocin |
| Telmisartan | 📋 | | ⛔ | | 40541176 | Telmisartan is neuroprotective in a hiPSC-derived spinal microtissue model for C9orf72 ALS via inhibition of neuroinflammation |
| Thymol | 📋 | ✍ | ⛔ | | 36808768 | Thymol in Trachyspermum ammi seed extract exhibits neuroprotection, learning, and memory enhancement in scopolamine-induced Alzheimer's disease mouse model |
| Trehalose | 📋 | | ⛔ | | 37542649 | Metformin and Trehalose-Modulated Autophagy Exerts a Neurotherapeutic Effect on Parkinson's Disease |
| Vitamin B7 | 📋 | ✍ | ⛔ | | 39035497 | The protective effect of biotin supplementation and swimming training on cognitive impairment and mental symptoms in a rat model of Alzheimer's disease: A behavioral, biochemical, and histological study |
| Vitamin K2 | 📋 | ✍ | ⛔ | | 40506698 | The epigenetic potential of vitamin K2 in brain health |
| Alpha-Linolenic Acid | 📋 | ✍ | ⛔ | | 40269665 | Alpha-Linolenic Acid for Mitigating Neuroinflammation and Dopaminergic Neuronal Loss in Parkinson's Disease: Insights From In Vivo and In Silico Studies |
| Betaine | 📋 | ✍ | ⛔ | | 40129881 | Betaine alleviates deficits in motor behavior, neurotoxic effects, and neuroinflammatory responses in a rat model of demyelination |
| Blueberry | 📋 | ✍ | ⛔ | | 37647279 | Blueberry extracts antagonize Aβ25-35 neurotoxicity and exert a neuroprotective effect through MEK-ERK-BDNF/UCH-L1 signaling pathway in rat and mouse hippocampus |
| Cinnamaldehyde | 📋 | | | | 39741957 | Cinnamaldehyde Attenuates the Expression of IBA1 and GFAP to Inhibit Glial Cell Activation and Inflammation in the MPTP-Induced Acute Parkinson's Disease Model |
| Crocetin | 📋 | | | | 38764638 | ADME/PK Insights of Crocetin: A Molecule Having an Unusual Chemical Structure with Druglike Features |
| Evening Primrose Oil | 📋 | ✍ | ⛔ | | 36464068 | Protective effects of evening primrose oil on behavioral activities, nigral microglia and histopathological changes in a rat model of rotenone-induced parkinsonism |
| Galangin | 📋 | | | | 40256391 | Galangin reduces MPTP-induced dopamine neuron injury via the autophagy dependent-PI3K/AKT pathway |
| Geniposide | 📋 | | | | 38762146 | Geniposide effectively safeguards HT22 cells against Aβ-induced damage by activating mitophagy via the PINK1/Parkin signaling pathway |
| Gingerol | 📋 | ✍ | | | 39982688 | Polypharmacology and Neuroprotective Effects of Gingerol in Alzheimer's Disease |
| Green Tea | 📋 | ✍ | ⛔ | | 36766162 | Computer-Aided Screening and Revealing Action Mechanism of Green Tea Polyphenols Intervention in Alzheimer's Disease |
| Licochalcones | 📋 | | | | 39437838 | Licochalcone A Ameliorates Cognitive Dysfunction in an Alzheimer's Disease Model by Inhibiting Endoplasmic Reticulum Stress-Mediated Apoptosis |
| Lotus | 📋 | | ⛔ | | 39756059 | Bioinformatics Exploration of the Therapeutic Potential of Lotus Seed Compounds in Multiple Sclerosis: A Network Analysis of c-Jun Pathway |
| Mucuna Pruriens | 📋 | ✍ | ⛔ | | 40137945 | Comparative efficacy of Mucuna pruriens and conventional levodopa in Parkinson's disease: a randomized controlled trial on pharmacokinetics and clinical perspectives from Asia |
| Nicotinamide | 📋 | ✍ | ⛔ | | 39671543 | Phase 2A Proof-of-Concept Double-Blind, Randomized, Placebo-Controlled Trial of Nicotinamide in Early Alzheimer Disease |
| Peony | 📋 | | ⛔ | | 40374370 | Neuroprotective Effects of Paeonia lactiflora Through the Regulation of Gut Dubosiella in an MPTP-Induced Parkinson's Disease Mouse Model |
| Rosemary | 📋 | ✍ | ⛔ | | 40055645 | Network pharmacology mechanism of Rosmarinus officinalis L.(Rosemary) to improve cell viability and reduces apoptosis in treating Alzheimer's disease |
| Spermidine | 📋 | | | | 40059454 | Spermidine Inhibits M1 Microglia Polarization in a Mouse Model of Parkinson's Disease and BV2 Cells via NF-?B/STAT-1 Pathway |
| St. Johns Wort | 📋 | ✍ | ⛔ | | 39812531 | Response of miRNA to treatment with Hypericum perforatum L. oil in multiple sclerosis |
| Stigmasterol | 📋 | | | | 39947740 | Focusing on Keap1, IKKβ, and Bcl2 proteins: predicted targets of stigmasterol in neurodegeneration |
| Stinging Nettle | 📋 | ✍ | ⛔ | | 38387425 | The role of stinging nettle (Urtica dioica L.) in the management of rotenone-induced Parkinson's disease in rats |
| Tangeretin | 📋 | | | | 38672774 | An Update on the Potential of Tangeretin in the Management of Neuroinflammation-Mediated Neurodegenerative Disorders |
| Tetrahydrocurcumin | 📋 | ✍ | | | 40332041 | The Role of Tetrahydrocurcumin in Tumor and Neurodegenerative Diseases Through Anti-Inflammatory Effects |
| Turmeric | 📋 | ✍ | ⛔ | | 35674299 | Neuroprotective potential of curcuminoids in modulating Alzheimer's Disease via multiple signaling pathways |
| Withaferin A | 📋 | | | | 40479066 | Vimentin network dysregulation mediates neurite deficits in SNCA duplication Parkinson's patient-derived midbrain neurons |
| Wormwood | 📋 | ✍ | ⛔ | | 36999542 | Mechanism and Molecular Targets of a Water-Soluble Extract of Artemisia annua on the Treatment of Alzheimer's Disease Based on Network Pharmacology and Experimental Validation |
| Angelica | 📋 | ✍ | ⛔ | | 35983893 | Medicine-food herb: Angelica sinensis, a potential therapeutic hope for Alzheimer's disease and related complications |
| Arctigenin | 📋 | | | | 38104254 | Arctigenin attenuated spatial memory impairment in pR5 mice by regulating mitochondrial energy metabolism |
| Beta-Carotene | 📋 | ✍ | ⛔ | | 36982248 | β-Carotene, a Potent Amyloid Aggregation Inhibitor, Promotes Disordered Aβ Fibrillar Structure |
| Biochanin A | 📋 | | | | 40012390 | Biochanin-A: A Potential Candidate for the Treatment of Alzheimer's Disease |
| Black Pepper | 📋 | ✍ | ⛔ | | 37237954 | Black Pepper ( Piper nigrum) Alleviates Oxidative Stress, Exerts Potential Anti-Glycation and Anti-AChE Activity: A Multitargeting Neuroprotective Agent against Neurodegenerative Diseases |
| Bromelain | 📋 | ✍ | ⛔ | | 40491365 | Exploring the Neuroprotective Potential of Polyphenolic Compounds in Mitigating Quinolinic Acid-Induced Neurotoxicity in Alzheimer's Disease |
| Capsaicin | 📋 | ✍ | ⛔ | | 37373321 | A Systematic Review of the Effects of Capsaicin on Alzheimer's Disease |
| Carnosol | 📋 | | | | 40465192 | Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulation Guided Discovery of Anethole, Carvacrol, Carnosol, Nicotine, and Paeonol as Potential Therapeutics for Parkinson's Disease |
| Daidzein | 📋 | ✍ | ⛔ | | 40359691 | Daidzein effectively mitigates amyloid-β-induced damage in SH-SY5Y neuroblastoma cells and C6 glioma cells |
| Fenugreek | 📋 | ✍ | ⛔ | | 40125337 | Anti-inflammatory and antioxidant effects of fenugreek in preventing mice model of Alzheimer's disease |
| Fish Oil | 📋 | ✍ | ⛔ | | 39273347 | The Impact of High-Dose Fish Oil Supplementation on Mfsd2a, Aqp4, and Amyloid-β Expression in Retinal Blood Vessels of 5xFAD Alzheimer's Mouse Model |
| Geraniol | 📋 | | | | 39587789 | Protective effects of geraniol in a male rat model of Alzheimer's disease: A behavioral, biochemical, and histological study |
| Grape | 📋 | | ⛔ | | 36613906 | Protective Effects of Currants ( Vitis vinifera) on Corticolimbic Serotoninergic Alterations and Anxiety-like Comorbidity in a Rat Model of Parkinson's Disease |
| Hawthorn | 📋 | ✍ | ⛔ | | 36447359 | Neuroprotective effects of hawthorn leaf flavonoids in Aβ25-35 -induced Alzheimer's disease model |
| Holy Basil | 📋 | ✍ | ⛔ | | 35900690 | Amelioration of intracerebroventricular streptozotocin-induced cognitive dysfunction by Ocimum sanctum L. through the modulation of inflammation and GLP-1 levels |
| L-Arginine | 📋 | ✍ | ⛔ | | 39326233 | L-arginine mitigates choroid plexus changes in Alzheimer's disease rat model via oxidative/inflammatory burden and behavioral modulation |
| Linalool | 📋 | | ⛔ | | 39199163 | Linalool and Geraniol Defend Neurons from Oxidative Stress, Inflammation, and Iron Accumulation in In Vitro Parkinson's Models |
| PEA | 📋 | ✍ | ⛔ | | 40313591 | Chronic palmitoylethanolamide administration via slow-release subcutaneous pellets promotes neuroprotection and mitigates neuroinflammation in the Tg2576 mouse model of Alzheimer's disease |
| Pomegranate Peel extract | 📋 | ✍ | ⛔ | | 35164175 | Healthy Properties of a New Formulation of Pomegranate-Peel Extract in Mice Suffering from Experimental Autoimmune Encephalomyelitis |
| PQQ | 📋 | ✍ | ⛔ | | 40234255 | Current study on Pyrroloquinoline quinone (PQQ) therapeutic role in neurodegenerative diseases |
| Tanshinone | 📋 | | | | 40083386 | The effect of tanshinones on cognitive impairments in animal models of Alzheimer's disease: a systematic review and meta-analysis |
| Tea | 📋 | | | | 39054894 | Tea, coffee, and caffeine intake and risk of dementia and Alzheimer's disease: a systematic review and meta-analysis of cohort studies |
| Vitamin B5 | 📋 | ✍ | ⛔ | | 34564384 | Substantively Lowered Levels of Pantothenic Acid (Vitamin B5) in Several Regions of the Human Brain in Parkinson's Disease Dementia |
| Vitamin B6 | 📋 | ✍ | ⛔ | | 39209095 | Management of Alzheimer's disease and related neurotoxic pathologies: Role of thiamine, pyridoxine and cobalamin |
| 5-HTP | 📋 | ✍ | ⛔ | | 36918741 | 5-Hydroxytryptophan Reduces Levodopa-Induced Dyskinesia via Regulating AKT/mTOR/S6K and CREB/ΔFosB Signals in a Mouse Model of Parkinson's Disease |
| Andrographis | 📋 | ✍ | ⛔ | | 38057817 | Ethanol extract of Andrographis paniculata alleviates aluminum-induced neurotoxicity and cognitive impairment through regulating the p62-keap1-Nrf2 pathway |
| Anethole | 📋 | | | | 40465192 | Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulation Guided Discovery of Anethole, Carvacrol, Carnosol, Nicotine, and Paeonol as Potential Therapeutics for Parkinson's Disease |
| Asparagus | 📋 | | ⛔ | | 40454371 | Exploring the neuroprotective role of Asparagus racemosus (Shatavari) in Alzheimer's disease: mechanisms, evidence, and future directions |
| Balloon Flower | 📋 | ✍ | ⛔ | | 40333841 | Role of Saponins from Platycodon grandiflorum in Alzheimer's Disease: DFT, Molecular Docking, and Simulation Studies in Key Enzymes |
| Caffeic Acid | 📋 | ✍ | ⛔ | | 37864768 | Implication of Caffeic Acid for the Prevention and Treatment of Alzheimer's Disease: Understanding the Binding with Human Transferrin Using In Silico and In Vitro Approaches |
| Calycosin | 📋 | | | | 39489278 | Demyelination in cuprizone mice is ameliorated by Calycosin mediated through astrocyte Nrf2 signaling pathway |
| CAPE | 📋 | | | | 37313025 | Caffeic Acid Phenethyl Ester With Mesenchymal Stem Cells Improves Behavioral and Histopathological Changes in the Rat Model of Parkinson Disease |
| Chokeberry | 📋 | ✍ | ⛔ | | 36978994 | Plant-Based Antioxidants for Prevention and Treatment of Neurodegenerative Diseases: Phytotherapeutic Potential of Laurus nobilis, Aronia melanocarpa, and Celastrol |
| Conjugated Linoleic Acid | 📋 | ✍ | ⛔ | | 38218550 | Dietary conjugated linoleic acid downregulates the AlCl3-induced hyperactivation of compensatory and maladaptive signalling in the mouse brain cortex |
| Coptis Chinensis | 📋 | | ⛔ | | 38599826 | Protective Effects of Coptis chinensis Rhizome Extract and Its Constituents (Berberine, Coptisine, and Palmatine) against α-Synuclein Neurotoxicity in Dopaminergic SH-SY5Y Cells |
| Cornus | 📋 | | | | 39946185 | Cornus mas ameliorates AlCl3-induced Alzheimer's disease in rats with metabolic syndrome by regulating inflammation and oxidative stress |
| Cyanidin | 📋 | ✍ | | | 40454491 | Anthocyanidins Intake is Associated with Alzheimer's Disease Risk in Americans over 60 Years of Age: Data from NHANES 2007-2008, 2009-2010, and 2017-2018 |
| Dioscin | 📋 | | | | 38024855 | Protective effects of dioscin against Parkinson's disease via regulating bile acid metabolism through remodeling gut microbiome/GLP-1 signaling |
| Diosgenin | 📋 | | | | 40480021 | Diosgenin promoted OPCs differentiation via blocking GLUR2/GAPDH interaction in a pilocarpine rat model of epilepsy |
| Diosmin | 📋 | ✍ | ⛔ | | 39105973 | Diosmin ameliorates inflammation, apoptosis and activates PI3K/AKT pathway in Alzheimer's disease rats |
| Ligustilide | 📋 | | | | 33111362 | Ligustilide alleviates neurotoxicity in SH-SY5Y cells induced by Aβ25-35 via regulating endoplasmic reticulum stress and autophagy |
| Nattokinase | 📋 | ✍ | ⛔ | | 40302732 | Abnormal Expression of Proteolytic Stress-Related Proteins and Protective Effect of Fibrinolytic Enzymes in Prion Diseases |
| Nootkatone | 📋 | | | | 38001852 | Astrocytic Nrf2 Mediates the Neuroprotective and Anti-Inflammatory Effects of Nootkatone in an MPTP-Induced Parkinson's Disease Mouse Model |
| Paeonol | 📋 | | | | 40465192 | Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulation Guided Discovery of Anethole, Carvacrol, Carnosol, Nicotine, and Paeonol as Potential Therapeutics for Parkinson's Disease |
| Phytoestrogens | 📋 | | ⛔ | | 39422947 | Alzheimer's Disease and (Phyto) Estrogen Treatment: Modification of Effects by Age, Type of Treatment, and Duration of Use |
| Postbiotics | 📋 | | | | 39952328 | Bridging gap in the treatment of Alzheimer's disease via postbiotics: Current practices and future prospects |
| Red Sage | 📋 | ✍ | ⛔ | | 40456474 | Proteomics based discovery of Salvia miltiorrhiza Bunge treating Parkinson's disease through the PINK1/Parkin pathway |
| Seaweeds | 📋 | | ⛔ | | 40137277 | The Advancements of Marine Natural Products in the Treatment of Alzheimer's Disease: A Study Based on Cell and Animal Experiments |
| Sesamin | 📋 | ✍ | | | 37539928 | Neuroprotective effects of Sesamum indicum, sesamin and sesamolin against 6-OHDA-induced apoptosis in PC12 cells |
| UDCA | 📋 | ✍ | ⛔ | | 39891787 | The effects of ursodeoxycholic acid on Parkinson's disease, a mechanistic review of the recent evidence |
| Zeaxanthin | 📋 | ✍ | ⛔ | | 39337316 | Zeaxanthin and Lutein Ameliorate Alzheimer's Disease-like Pathology: Modulation of Insulin Resistance, Neuroinflammation, and Acetylcholinesterase Activity in an Amyloid-β Rat Model |
| Acai Berry | 📋 | ✍ | ⛔ | | 37109548 | Acai Berry ( Euterpe sp.) Extracts Are Neuroprotective against L-Glutamate-Induced Toxicity by Limiting Mitochondrial Dysfunction and Cellular Redox Stress |
| Apple Vinegar | 📋 | ✍ | ⛔ | | 39531579 | Inhibitory Potency of Chlorogenic Acid from Apple Cider Vinegar Against Alzheimer's Disease: Molecular Docking and Dynamics Validation |
| Aspirin | 📋 | | ⛔ | | 36846997 | Aspirin Use and Risk of Alzheimer's Disease: A 2-Sample Mendelian Randomization Study |
| Basil | 📋 | ✍ | ⛔ | | 35000160 | Potential innovation against Alzheimer's disorder: a tricomponent combination of natural antioxidants (vitamin E, quercetin, and basil oil) and the development of its intranasal delivery |
| Benfotiamine | 📋 | ✍ | ⛔ | | 27696179 | Long-Term Cognitive Improvement After Benfotiamine Administration in Patients with Alzheimer's Disease |
| Bilberry | 📋 | ✍ | ⛔ | | 40321611 | In Vitro Evaluation of Antidiabetic, Antioxidant, and Anticholinergic Properties of Different Parts of Bilberry (Vaccinium myrtillus L.) From the Eastern Black Sea Region, With LC/MS-MS Analysis of Their Chemical Composition in Food Applications |
| Blackberry | 📋 | | ⛔ | | 38430352 | Treatment with Blackberry Extract and Metformin in Sporadic Alzheimer's Disease Model: Impact on Memory, Inflammation, Redox Status, Phosphorylated Tau Protein and Insulin Signaling |
| Blackcurrant | 📋 | ✍ | ⛔ | | 35790009 | Anthocyanin-rich blackcurrant extract improves long-term memory impairment and emotional abnormality in senescence-accelerated mice |
| Chicoric Acid | 📋 | | | | 40123433 | Chicoric acid alleviates rotenone-induced motor dysfunction in mice: Targeting PI3K/AKT/caspase-3-associated apoptosis and neuroinflammation |
| Copper | 📋 | ✍ | ⛔ | | 37800457 | Fundamental Neurochemistry Review: Copper availability as a potential therapeutic target in progressive supranuclear palsy: Insight from other neurodegenerative diseases |
| Cordyceps | 📋 | ✍ | ⛔ | | 40508211 | Preclinical Evidence of Withania somnifera and Cordyceps spp.: Neuroprotective Properties for the Management of Alzheimer's Disease |
| Coumaric acid | 📋 | | | | 37414223 | p-Coumaric acid attenuates the effects of Aβ42 in vitro and in a Drosophila Alzheimer's disease model |
| Dandelion | 📋 | ✍ | ⛔ | | 35053874 | Herbal Mixture of Carthamus tinctorius L. Seed and Taraxacum coreanum Attenuates Amyloid Beta-Induced Cognitive Dysfunction In Vivo |
| DHEA | 📋 | ✍ | ⛔ | | 40002846 | Neuroprotective Effects of Dehydroepiandrosterone Sulphate Against A? Toxicity and Accumulation in Cellular and Animal Model of Alzheimer's Disease |
| Diosmetin | 📋 | | | | 39323333 | Investigating In Silico and In Vitro Therapeutic Potential of Diosmetin as the Anti-Parkinson Agent |
| Essential Oils | 📋 | | ⛔ | | 39921369 | Treatments of psychosomatic symptoms in Alzheimer's disease: a scoping review of the potential therapeutic effects of essential oils |
| Eucommia | 📋 | ✍ | ⛔ | | 40141407 | Identification of Key Active Constituents in Eucommia ulmoides Oliv. Leaves Against Parkinson's Disease and the Alleviative Effects via 4E-BP1 Up-Regulation |
| Fo-Ti Root | 📋 | ✍ | ⛔ | | 40051562 | Ginseng and Polygonum multiflorum formula protects brain function in Alzheimer's disease |
| Folate | 📋 | ✍ | ⛔ | | 37735121 | Features of Plasma Homocysteine, Vitamin B12, and Folate in Parkinson's Disease: An Updated Meta-Analysis |
| Galangal | 📋 | ✍ | ⛔ | | 36306920 | Combination of Alpinia Oxyphylla Fructus and Schisandra Chinensis Fructus Ameliorates Aluminum-induced Alzheimer's Disease via reducing BACE1 Expression |
| Glycyrrhizic Acid | 📋 | ✍ | ⛔ | | 40346511 | Identifying suppressive factors of Alzheimer's disease through comprehensive analysis of real-world data: a single-center retrospective study |
| Haritaki | 📋 | ✍ | ⛔ | | 35696798 | Autophagy activation by Terminalia chebula Retz. reduce Aβ generation by shifting APP processing toward non-amyloidogenic pathway in APPswe transgenic SH-SY5Y cells |
| Hemp Oil | 📋 | ✍ | ⛔ | | 30936931 | Regulatory effects of hemp seed/evening primrose oil supplement in comparison with rapamycin on the expression of the mammalian target of rapamycin-complex 2 and interleukin-10 genes in experimental autoimmune encephalomyelitis |
| Indian Gooseberry | 📋 | | ⛔ | | 38030098 | Aqueous leaf extract of Phyllanthus amarus protects against oxidative stress and misfiring of dopaminergic neurons in Paraquat-induced Parkinson's disease-like model of adult Wistar rats |
| Lauric Acid | 📋 | ✍ | | | 40418323 | Effects of lauric acid on cognitive impairment in a scopolamine-induced Alzheimer's disease-like rat model |
| Lavender Essential Oil | 📋 | ✍ | ⛔ | | 33305625 | Comparing the effects of vestibular rehabilitation with and without lavender oil scents as an olfactory stimulus on balance, fear of falling down and activities of daily living of people with multiple sclerosis: a randomized clinical trial |
| Liquiritigenin | 📋 | | | | 33965487 | Exploring the inhibitory effects of liquiritigenin against tau fibrillation and related neurotoxicity as a model of preventive care in Alzheimer's disease |
| Neferine | 📋 | | | | 37921051 | Neferine exerts anti‑inflammatory activity in BV-2 microglial cells and protects mice with MPTP-induced Parkinson's disease by inhibiting NFκB activation |
| Oleanolic Acid | 📋 | | | | 40537615 | Oleanolic acid activates the JNK-Sp1-DJ-1 axis to promote mitophagy-mediated neuroprotection in dopaminergic neurons for Parkinson's disease treatment |
| Parthenolide | 📋 | | | | 40100917 | Parthenolide regulates microglial and astrocyte function in primary cultures from ALS mice and has neuroprotective effects on primary motor neurons |
| Patchouli | 📋 | ✍ | ⛔ | | 38996935 | The effect and mechanism of patchouli alcohol on cognitive dysfunction in AD mice induced by Aβ1-42 oligomers through AMPK/mTOR pathway |
| Persimmon | 📋 | | ⛔ | | 34205542 | Immature Persimmon Suppresses Amyloid Beta (Aβ) Mediated Cognitive Dysfunction via Tau Pathology in ICR Mice |
| Plum | 📋 | | ⛔ | | 30577585 | Potential Application of Prunus armeniaca L. and P. domestica L. Leaf Essential Oils as Antioxidant and of Cholinesterases Inhibitors |
| Procyanidins | 📋 | | ⛔ | | 34770830 | Neuroprotective Effects of B-Type Cinnamon Procyanidin Oligomers on MPP +-Induced Apoptosis in a Cell Culture Model of Parkinson's Disease |
| Progesterone | 📋 | ✍ | ⛔ | | 37190115 | Progesterone: A Neuroprotective Steroid of the Intestine |
| Roselle | 📋 | ✍ | ⛔ | | 35159249 | A Distinct Hibiscus sabdariffa Extract Prevents Iron Neurotoxicity, a Driver of Multiple Sclerosis Pathology |
| Royal Jelly | 📋 | ✍ | ⛔ | | 36809522 | Royal jelly improves learning and memory deficits in an amyloid β-induced model of Alzheimer's disease in male rats: Involvement of oxidative stress |
| Sage | 📋 | ✍ | ⛔ | | 40266402 | A network pharmacology-based approach to decipher the pharmacological mechanisms of Salvia officinalis in neurodegenerative disorders |
| Sea Buckthorn | 📋 | ✍ | ⛔ | | 39984555 | Nebulized seabuckthorn seed oil inhalation attenuates Alzheimer's disease progression in APP/PS1 mice |
| Shogaol | 📋 | | | | 40063144 | 6-Shogaol, a neuro-nutraceutical derived from ginger, alleviates motor symptoms and depression-like behaviors and modulates the release of monoamine neurotransmitters in Parkinson's disease mice |
| Spices | 📋 | | | | 34279199 | Effects of Spices (Saffron, Rosemary, Cinnamon, Turmeric and Ginger) in Alzheimer's Disease |
| Tannic Acid | 📋 | ✍ | ⛔ | | 37712018 | A natural polyphenol activates and enhances GPX4 to mitigate amyloid-β induced ferroptosis in Alzheimer's disease |
| Vitamin B3 | 📋 | ✍ | ⛔ | | 39091685 | Association between dietary niacin intake and risk of Parkinson's disease in US adults: cross-sectional analysis of survey data from NHANES 2005-2018 |
| Acacetin | 📋 | | | | 36382256 | Acacetin improves cognitive function of APP/PS1 Alzheimer's disease model mice via the NLRP3 inflammasome signaling pathway |
| Aloe Vera | 📋 | ✍ | ⛔ | | 35807891 | Involvement of the Intestinal Microbiota in the Appearance of Multiple Sclerosis: Aloe vera and Citrus bergamia as Potential Candidates for Intestinal Health |
| Aloe-Emodin | 📋 | | | | 40125832 | Aloe-Emodin Improves Mitophagy in Alzheimer's Disease via Activating the AMPK/PGC-1α/SIRT3 Signaling Pathway |
| Asafoetida | 📋 | ✍ | ⛔ | | 36857494 | Acetylcholinesterase inhibitory activity of Ferula plants and their potential for treatment of Alzheimer's disease |
| Astragalin | 📋 | | | | 40032030 | Astragalin actives autophagy and inhibits apoptosis of astrocytes in AD mice via down-regulating Fas/Fasl-VDAC1 pathway |
| Atractylodes | 📋 | ✍ | ⛔ | | 36164880 | [Mechanism of Atractylodes macrocephala against Alzheimer's disease via regulating lysophagy based on LKB1-AMPK-TFEB pathway] |
| Barberry | 📋 | ✍ | ⛔ | | 39989392 | Identification of potential inhibitors of Fyn-Kinase from bioactive phytochemicals of Berberis lycium for therapeutic targeting of neurodegenerative disease |
| Bergamot | 📋 | ✍ | ⛔ | | 35807891 | Involvement of the Intestinal Microbiota in the Appearance of Multiple Sclerosis: Aloe vera and Citrus bergamia as Potential Candidates for Intestinal Health |
| Berries | 📋 | | | | 29401686 | Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effects |
| Beta-Lapachone | 📋 | | | | 39933959 | Neuroprotective Effect of β-Lapachone against Glutamate-Induced Injury in HT22 Cells |
| Betulinic Acid | 📋 | | | | 40203997 | Betulinic acid protects against lipopolysaccharide and ferrous sulfate-induced oxidative stress, ferroptosis, apoptosis, and neuroinflammation signaling relevant to Parkinson's Disease |
| Boric Acid | 📋 | ✍ | ⛔ | | 37220543 | Therapeutic Efficacy of Boric Acid Treatment on Brain Tissue and Cognitive Functions in Rats with Experimental Alzheimer's Disease |
| Chaga Mushrooms | 📋 | ✍ | ⛔ | | 40429872 | INO10, a Chaga Mushroom Extract, Alleviates Alzheimer's Disease-Related Pathology and Cognitive Deficits in 3xTg-AD Mice |
| Clove | 📋 | | ⛔ | | 37851769 | Neuroprotective effects of a combination of Boswellia papyrifera and Syzygium aromaticum on AlCl3 induced Alzheimer's disease in male albino rat |
| Coconut | 📋 | | ⛔ | | 29188860 | A Keto-Mediet Approach with Coconut Substitution and Exercise May Delay the Onset of Alzheimer's Disease among Middle-Aged |
| Coriander | 📋 | | ⛔ | | 35922685 | Heated Leaf Extract of Coriandrum sativum L. Protects Nigral Dopaminergic Degeneration in Rats |
| Coriander Essential Oil | 📋 | ✍ | ⛔ | | 32785956 | Lavender and coriander essential oils and their main component linalool exert a protective effect against amyloid-β neurotoxicity |
| Date | 📋 | | ⛔ | | 36654869 | Effects of Phoenix dactylifera against Streptozotocin-Aluminium Chloride Induced Alzheimer's Rats and Their In Silico Study |
| Eleuthero | 📋 | ✍ | ⛔ | | 40332373 | Acanthopanax Senticosus Saponins Prevent Cognitive Decline in Rats with Alzheimer's Disease |
| Escin | 📋 | ✍ | ⛔ | | 40095493 | Pharmacological Evaluation of Aescin for Neuroprotection in Intracerebroventricular Streptozotocin Model of Alzheimer's Disease in Experimental Rats |
| Forskolin | 📋 | ✍ | ⛔ | | 36614135 | Intranasal Administration of Forskolin and Noopept Reverses Parkinsonian Pathology in PINK1 Knockout Rats |
| Gardenia | 📋 | | ⛔ | | 38000495 | Gardenia jasminoides J. Ellis extract attenuates memory impairment in rats with Alzheimer's disease by suppressing NLRP3 inflammasome |
| Genipin | 📋 | | | | 37865990 | Genipin and pyrogallol: Two natural small molecules targeting the modulation of disordered proteins in Alzheimer's disease |
| Geranium | 📋 | | | | 39921688 | Pelargonium graveolens Attenuates Rotenone-Induced Parkinson's Disease in a Rat Model: Role of MAO-B Inhibition and In Silico Study |
| Giloy | 📋 | ✍ | ⛔ | | 40057579 | Network pharmacology and metabolomics analysis of Tinospora cordifolia reveals BACE1 and MAOB as potential therapeutic targets for neuroprotection in Alzheimer's disease |
| Guggulsterone | 📋 | | | | 38170440 | Guggulsterone Selectively Modulates STAT-3, mTOR, and PPAR-Gamma Signaling in a Methylmercury-Exposed Experimental Neurotoxicity: Evidence from CSF, Blood Plasma, and Brain Samples |
| Hazelnut | 📋 | | ⛔ | | 38151890 | Does hazelnut consumption affect brain health and function against neurodegenerative diseases? |
| HMB | 📋 | ✍ | ⛔ | | 38419348 | Muscle-building supplement β-hydroxy β-methylbutyrate stimulates the maturation of oligodendroglial progenitor cells to oligodendrocytes |
| Kudzu Root | 📋 | ✍ | ⛔ | | 33433542 | In silico-determined compound from the root of Pueraria lobate alleviates synaptic plasticity injury induced by Alzheimer's disease via the p38MAPK-CREB signaling pathway |
| Lactobacillus plantarum | 📋 | | ⛔ | | 38924882 | NMN synbiotics intervention modulates gut microbiota and metabolism in APP/PS1 Alzheimer's disease mouse models |
| Lemon Balm | 📋 | ✍ | ⛔ | | 33122694 | Safety and efficacy of Melissa officinalis extract containing rosmarinic acid in the prevention of Alzheimer's disease progression |
| Linoleic Acid | 📋 | ✍ | ⛔ | | 35892594 | Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson's Disease: The Implication of Lipid Droplets and Lipophagy |
| Lychee | 📋 | | ⛔ | | 31917277 | Polyphenols isolated from lychee seed inhibit Alzheimer's disease-associated Tau through improving insulin resistance via the IRS-1/PI3K/Akt/GSK-3β pathway |
| Madecassoside | 📋 | | | | 38181970 | Protective role of madecassoside from Centella asiatica against protein L-isoaspartyl methyltransferase deficiency-induced neurodegeneration |
| Malvidin | 📋 | | | | 40454491 | Anthocyanidins Intake is Associated with Alzheimer's Disease Risk in Americans over 60 Years of Age: Data from NHANES 2007-2008, 2009-2010, and 2017-2018 |
| Nutmeg | 📋 | ✍ | ⛔ | | 35662922 | Inhibitory Effects of Macelignan on Tau Phosphorylation and Aβ Aggregation in the Cell Model of Alzheimer's Disease |
| Pantethine | 📋 | ✍ | ⛔ | | 39501296 | Coenzyme A fueling with pantethine limits autoreactive T cell pathogenicity in experimental neuroinflammation |
| Pelargonidin | 📋 | | | | 35694918 | Pelargonidin and Berry Intake Association with Alzheimer's Disease Neuropathology: A Community-Based Study |
| Polydatin | 📋 | ✍ | | | 40313624 | Polydatin attenuates Alzheimer's disease induced by aluminum chloride in rats: evidence for its antioxidant and anti-inflammatory effects |
| Pregnenolone | 📋 | ✍ | ⛔ | | 36878398 | Pregnenolone for the treatment of L-DOPA-induced dyskinesia in Parkinson's disease |
| Pu-erh Tea | 📋 | ✍ | ⛔ | | 32992081 | Pu'er tea water extract protects against cognitive impairment in a mouse model of lipopolysaccharide-induced neuroinflammation |
| PUFA | 📋 | | | | 16679766 | Polyunsaturated fatty acid supplementation stimulates differentiation of oligodendroglia cells |
| Rehmannia | 📋 | ✍ | ⛔ | | 35784741 | Neuroprotective Effects of Oligosaccharides in Rehmanniae Radix on Transgenic Caenorhabditis elegans Models for Alzheimer's Disease |
| Rosemary Essential Oil | 📋 | ✍ | ⛔ | | 36986277 | Rosmarinus officinalis and Mentha piperita Oils Supplementation Enhances Memory in a Rat Model of Scopolamine-Induced Alzheimer's Disease-like Condition |
| Safranal | 📋 | | | | 38683404 | Safranal exerts a neuroprotective effect on Parkinson's disease with suppression of NLRP3 inflammation activation |
| Scutellarin | 📋 | | | | 40152387 | Scutellarin Attenuates Pro-Inflammatory Foam Cell Formation and Facilitates M2 Polarization in Microglia during Copper Homeostasis Imbalance via the MAPK Signaling Pathway |
| Sesamol | 📋 | | | | 34669408 | Sesamol Attenuates Amyloid Peptide Accumulation and Cognitive Deficits in APP/PS1 Mice: The Mediating Role of the Gut-Brain Axis |
| Soy | 📋 | ✍ | ⛔ | | 35634410 | Effect of Fermentation on the Bioactive Compounds of the Black Soybean and Their Anti-Alzheimer's Activity |
| Strawberry | 📋 | ✍ | ⛔ | | 33547659 | Strawberry (Fragaria ananassa duch.) Alba extract attenuates DNA damage in lymphocytes of patients with Alzheimer's disease |
| Tribulus Terrestris | 📋 | ✍ | ⛔ | | 33043200 | Anti-Parkinson's Activity of Tribulus terrestris via Modulation of AChE, α-Synuclein, TNF-α, and IL-1β |
| Valerian Root | 📋 | ✍ | ⛔ | | 31909290 | "Effect of valerenic acid on neuroinflammation in a MPTP-induced mouse model of Parkinson's disease" |
| Vitamin K | 📋 | ✍ | ⛔ | | 39346641 | Dietary vitamin K intake is associated with decreased neurofilament light chain among middle-aged and older adults from the NHANES |
| Wogonin | 📋 | ✍ | ⛔ | | 33147823 | Neuroprotective Effects of Baicalein, Wogonin, and Oroxylin A on Amyloid Beta-Induced Toxicity via NF-κB/MAPK Pathway Modulation |
| Anthocyanidins | 📋 | | | | 40454491 | Anthocyanidins Intake is Associated with Alzheimer's Disease Risk in Americans over 60 Years of Age: Data from NHANES 2007-2008, 2009-2010, and 2017-2018 |
| Apple | 📋 | | ⛔ | | 31837654 | Neuroprotective Effects of Apple-Derived Drinks in a Mice Model of Inflammation |
| Basil Essential Oil | 📋 | ✍ | ⛔ | | 31997265 | Ocimum basilicum attenuates ethidium bromide-induced cognitive deficits and pre-frontal cortical neuroinflammation, astrogliosis and mitochondrial dysfunction in rats |
| Bay Leaf | 📋 | | ⛔ | | 36978994 | Plant-Based Antioxidants for Prevention and Treatment of Neurodegenerative Diseases: Phytotherapeutic Potential of Laurus nobilis, Aronia melanocarpa, and Celastrol |
| Beets | 📋 | ✍ | ⛔ | | 38887650 | Exploring beetroot (Beta vulgaris L.) for diabetes mellitus and Alzheimer's disease dual therapy: in vitro and computational studies |
| Bitter Melon | 📋 | ✍ | ⛔ | | 36902074 | The Effects of Momordica charantia on Type 2 Diabetes Mellitus and Alzheimer's Disease |
| Bitter Orange | 📋 | ✍ | ⛔ | | 38078339 | Activity of Citrus aurantium and Lavandula angustifolia in Alzheimer's Disease Symptoms in Male Wistar Rats |
| Black Ginger | 📋 | ✍ | ⛔ | | 40063637 | Kaempferia parviflora extract and its methoxyflavones as potential anti-Alzheimer assessing in vitro, integrated computational approach, and in vivo impact on behaviour in scopolamine-induced amnesic mice |
| Black Tea | 📋 | ✍ | ⛔ | | 22138428 | Theaflavin, a black tea polyphenol, protects nigral dopaminergic neurons against chronic MPTP/probenecid induced Parkinson's disease |
| Cardamom | 📋 | ✍ | ⛔ | | 39673650 | Targeting Neuroinflammation and Apoptosis: Cardamonin's Cognitive Benefits in Alzheimer's 5XFAD Mice |
| Cardamonin | 📋 | | | | 39673650 | Targeting Neuroinflammation and Apoptosis: Cardamonin's Cognitive Benefits in Alzheimer's 5XFAD Mice |
| Cat's Claw | 📋 | ✍ | ⛔ | | 38310572 | Comprehensive In Silico Analysis of Uncaria Tomentosa Extract: Chemical Profiling, Antioxidant Assessment, and CLASP Protein Interaction for Drug Design in Neurodegenerative Diseases |
| Cherry | 📋 | | ⛔ | | 27578256 | Tart cherry supplementation improves working memory, hippocampal inflammation, and autophagy in aged rats |
| Cinnamic Acid | 📋 | | | | 33662757 | A review on ferulic acid and analogs based scaffolds for the management of Alzheimer's disease |
| Cranberry | 📋 | ✍ | ⛔ | | 35631155 | Neuroprotective Effects of Cranberry Juice Treatment in a Rat Model of Parkinson's Disease |
| Cryptotanshinone | 📋 | | | | 36124540 | Cryptotanshinone protects against oxidative stress in the paraquat-induced Parkinson's disease model |
| D-Mannose | 📋 | ✍ | ⛔ | | 34814011 | Oral D-mannose treatment suppresses experimental autoimmune encephalomyelitis via induction of regulatory T cells |
| Dihydroartemisinin | 📋 | | | | 39910679 | Therapeutic effect of dihydroartemisinin on Alzheimer's disease model mice with senile macular degeneration |
| Elderberry | 📋 | ✍ | ⛔ | | 33745925 | Elderberry diet ameliorates motor function and prevents oxidative stress-induced cell death in rat models of Huntington disease |
| Eucalyptus | 📋 | ✍ | ⛔ | | 39486370 | Effect of bioactive extracts from Eucalyptus globulus leaves in experimental models of Alzheimer's disease |
| Fatty Acids | 📋 | | | | 34831163 | Medium-Chain Length Fatty Acids Enhance Aβ Degradation by Affecting Insulin-Degrading Enzyme |
| Fermented Foods | 📋 | | ⛔ | | 37967591 | Does a pickle a day keep Alzheimer's away? Fermented food in Alzheimer's disease: A review |
| Fruits | 📋 | | | | 38347678 | Causal association between plant foods intake and Alzheimer's disease: a Mendelian randomization study |
| GABA | 📋 | ✍ | ⛔ | | 36734072 | The molecular mechanism of γ-aminobutyric acid against AD: the role of CEBPα/circAPLP2/miR-671-5p in regulating CNTN1/2 expression |
| Gamma-Linolenic Acid | 📋 | ✍ | ⛔ | | 16679766 | Polyunsaturated fatty acid supplementation stimulates differentiation of oligodendroglia cells |
| Ginkgolic Acid | 📋 | | | | 39870805 | Age-related p53 SUMOylation accelerates senescence and tau pathology in Alzheimer's disease |
| Glutathione | 📋 | ✍ | ⛔ | | 35310529 | Olive polyphenols and bioavailable glutathione: Promising results in patients diagnosed with mild Alzheimer's disease |
| Honey | 📋 | ✍ | ⛔ | | 37570596 | Apitherapy in Post-Ischemic Brain Neurodegeneration of Alzheimer's Disease Proteinopathy: Focus on Honey and Its Flavonoids and Phenolic Acids |
| Horny Goat Weed | 📋 | ✍ | ⛔ | | 35165207 | The neuroprotective effects of icariin on ageing, various neurological, neuropsychiatric disorders, and brain injury induced by radiation exposure |
| Indian Mulberry | 📋 | ✍ | ⛔ | | 36158563 | Neuroprotective effects of Morinda officinalis How.: Anti-inflammatory and antioxidant roles in Alzheimer's disease |
| Isoflavones | 📋 | ✍ | ⛔ | | 34751296 | Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson's disease models |
| Isorhamnetin | 📋 | | | | 39560297 | Isorhamnetin Ameliorates Dopaminergic Neuronal Damage via Targeting FOSL1 to Activate AKT/mTOR in 6-OHDA-induced SH-SY5Y Cells |
| L-Carnitine Tartrate | 📋 | ✍ | ⛔ | | 38672280 | Combined Metabolic Activators with Different NAD+ Precursors Improve Metabolic Functions in the Animal Models of Neurodegenerative Diseases |
| L-Methionine | 📋 | ✍ | ⛔ | | 34573099 | L-Methionine Protects against Oxidative Stress and Mitochondrial Dysfunction in an In Vitro Model of Parkinson's Disease |
| L-Tryptophan | 📋 | ✍ | ⛔ | | 34105899 | Tryptophan in the diet ameliorates motor deficits in a rotenone-induced rat Parkinson's disease model via activating the aromatic hydrocarbon receptor pathway |
| Lavender | 📋 | ✍ | ⛔ | | 38078339 | Activity of Citrus aurantium and Lavandula angustifolia in Alzheimer's Disease Symptoms in Male Wistar Rats |
| Liquiritin | 📋 | | | | 27589374 | Neuroprotective effects of liquiritin on cognitive deficits induced by soluble amyloid-β 1-42 oligomers injected into the hippocampus |
| Long Pepper | 📋 | | ⛔ | | 26232071 | Protection effect of piperine and piperlonguminine from Piper longum L. alkaloids against rotenone-induced neuronal injury |
| Lupeol | 📋 | | | | 38842663 | Beneficial effect of lupeol and metformin in mouse model of intracerebroventricular streptozotocin induced dementia |
| Marigold | 📋 | ✍ | ⛔ | | 38268908 | Active compounds from Calendula officinalis flowers act via PI3K and ERK signaling pathways to offer neuroprotective effects against Parkinson's disease |
| Minerals | 📋 | | | | 40507121 | Actual Data on Essential Trace Elements in Parkinson's Disease |
| Neohesperidin | 📋 | | | | 38226659 | Orally administered neohesperidin attenuates MPTP-induced neurodegeneration by inhibiting inflammatory responses and regulating intestinal flora in mice |
| Omega-6 Fatty Acids | 📋 | ✍ | ⛔ | | 37445890 | DHA/EPA (Omega-3) and LA/GLA (Omega-6) as Bioactive Molecules in Neurodegenerative Diseases |
| Onion | 📋 | ✍ | ⛔ | | 38688382 | Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell |
| Oolong Tea | 📋 | | ⛔ | | 35629970 | Metabolomics Study Suggests the Mechanism of Different Types of Tieguanyin (Oolong) Tea in Alleviating Alzheimer's Disease in APP/PS1 Transgenic Mice |
| Oregano Essential Oil | 📋 | ✍ | ⛔ | | 35201555 | A multi-parameter evaluation of the neuroprotective and cognitive-enhancing effects of Origanum onites L. (Turkish Oregano) essential oil on scopolamine-induced amnestic rats |
| Perilla | 📋 | ✍ | | | 39554352 | Cold-pressed perilla seed oil: Investigating its protective influence on the gut-brain axis in mice with rotenone-induced Parkinson's disease |
| Phloretin | 📋 | | | | 36463449 | Neuroprotective Effect of Phloretin in Rotenone-Induced Mice Model of Parkinson's Disease: Modulating mTOR-NRF2-p62 Mediated Autophagy-Oxidative Stress Crosstalk |
| Phosphatidylserine | 📋 | ✍ | ⛔ | | 35992593 | Phosphatidylserine, inflammation, and central nervous system diseases |
| Pistachio | 📋 | ✍ | ⛔ | | 40384990 | Therapeutic Potential of Pistachio Green Hull Extract in Treating Parkinson's Disease: A Comprehensive In Vivo and In Vitro Investigation |
| Poria Mushrooms | 📋 | ✍ | | | 40254847 | Poria cocos Polysaccharide Reshapes Gut Microbiota to Regulate Short-Chain Fatty Acids and Alleviate Neuroinflammation-Related Cognitive Impairment in Alzheimer's Disease |
| Quercitrin | 📋 | | | | 36292931 | The Flavonol Quercitrin Hinders GSK3 Activity and Potentiates the Wnt/β-Catenin Signaling Pathway |
| Raspberry | 📋 | ✍ | ⛔ | | 30397021 | Identification and Microbial Production of the Raspberry Phenol Salidroside that Is Active against Huntington's Disease |
| Rhodiola | 📋 | ✍ | ⛔ | | 32058218 | Amelioration of experimental autoimmune encephalomyelitis by Rhodiola rosea, a natural adaptogen |
| Rose Essential Oil | 📋 | | | | 38688895 | A comprehensive assessment of the cholinergic-supporting and cognitive-enhancing effects of Rosa damascena Mill. (Damask rose) essential oil on scopolamine-induced amnestic rats |
| Safflower | 📋 | ✍ | ⛔ | | 35940347 | Preventive effects of a standardized flavonoid extract of safflower in rotenone-induced Parkinson's disease rat model |
| SAMe | 📋 | ✍ | ⛔ | | 32925070 | S-Adenosylmethionine Rescues Cognitive Deficits in the rTg4510 Animal Model by Stabilizing Protein Phosphatase 2A and Reducing Phosphorylated Tau |
| Serrapeptase | 📋 | ✍ | ⛔ | | 35694981 | The potential of lumbrokinase and serratiopeptidase for the degradation of Aβ 1-42 peptide - an in vitro and in silico approach |
| Sirtuin Activators | 📋 | | | | 36306110 | SIRT1 activation and its circadian clock control: a promising approach against (frailty in) neurodegenerative disorders |
| Sorghum | 📋 | | ⛔ | | 38740315 | The identification of active compounds and therapeutic properties of fermented and non-fermented red sorghum for the treatment of Alzheimer's dementia |
| Soy Protein | 📋 | ✍ | ⛔ | | 39717252 | Protective Effect of Whey Protein Supplement Against Rotenone Induced Motor Dysfunction in a Rat Model of Parkinson Disease |
| Syringic Acid | 📋 | | | | 34599991 | Syringic acid demonstrates promising protective effect against tau fibrillization and cytotoxicity through regulation of endoplasmic reticulum stress-mediated pathway as a prelude to Alzheimer's disease |
| Theaflavins | 📋 | ✍ | | | 22634505 | Theaflavin ameliorates behavioral deficits, biochemical indices and monoamine transporters expression against subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson's disease |
| Thyme | 📋 | ✍ | ⛔ | | 40188599 | Neuroprotective effect of Thymus vulgaris on paraquat induced Parkinson's disease |
| Trans-Resveratrol | 📋 | | | | 40362855 | Neuroprotective Effects of a Combination of Dietary Trans-Resveratrol and Hesperidin Against Methylglyoxal-Induced Neurotoxicity in a Depressive Amnesia Mouse Model |
| Vitamin B2 | 📋 | ✍ | ⛔ | | 29085589 | Update on riboflavin and multiple sclerosis: a systematic review |
| Vitex | 📋 | ✍ | ⛔ | | 35268709 | In Vivo Assessment of the Ameliorative Impact of Some Medicinal Plant Extracts on Lipopolysaccharide-Induced Multiple Sclerosis in Wistar Rats |
| Vitexin | 📋 | | | | 37102042 | Beneficial Role of Vitexin in Parkinson's Disease |
| Almond | 📋 | | ⛔ | | 29208493 | Almond, hazelnut and walnut, three nuts for neuroprotection in Alzheimer's disease: A neuropharmacological review of their bioactive constituents |
| Aloin | 📋 | | | | 35421539 | Structural and mechanistic insights into modulation of α-Synuclein fibril formation by aloin and emodin |
| Alpha GPC | 📋 | ✍ | ⛔ | | 38595916 | Pharmacological enhancement of cholinergic neurotransmission alleviates neuroinflammation and improves functional outcomes in a triple transgenic mouse model of Alzheimer's disease |
| Amino Acids | 📋 | | | | 35471671 | The potential roles of amino acids and their major derivatives in the management of multiple sclerosis |
| Apple Polyphenols | 📋 | | ⛔ | | 33466604 | Annurca Apple Polyphenol Extract Affects Acetyl- Cholinesterase and Mono-Amine Oxidase In Vitro Enzyme Activity |
| Apricot | 📋 | | ⛔ | | 36212969 | Pharmacological Potential of the Standardized Methanolic Extract of Prunus armeniaca L. in the Haloperidol-Induced Parkinsonism Rat Model |
| Arachidonic Acid | 📋 | ✍ | ⛔ | | 33803760 | Docosahexaenoic and Arachidonic Acids as Neuroprotective Nutrients throughout the Life Cycle |
| Arctiin | 📋 | | | | 39136502 | Therapeutic Effects of Arctiin on Alzheimer's Disease-like Model in Rats by Reducing Oxidative Stress, Inflammasomes and Fibrosis |
| Argan Oil | 📋 | ✍ | ⛔ | | 29065513 | Argan Oil-Mediated Attenuation of Organelle Dysfunction, Oxidative Stress and Cell Death Induced by 7-Ketocholesterol in Murine Oligodendrocytes 158N |
| Ashitaba | 📋 | ✍ | ⛔ | | 37403256 | The neuroprotective effects of Chalcones from Ashitaba on cuprizone-induced demyelination via modulation of brain-derived neurotrophic factor and tumor necrosis factor α |
| Avocado | 📋 | ✍ | ⛔ | | 27651262 | Avocado as a Major Dietary Source of Antioxidants and Its Preventive Role in Neurodegenerative Diseases |
| Bamboo | 📋 | ✍ | ⛔ | | 38334213 | The alleviative effects comparison of four flavonoids from bamboo leaves on ulcerative colitis in an Alzheimer mouse model |
| Beta-Glucan | 📋 | ✍ | ⛔ | | 36890624 | β-Glucan attenuates cognitive impairment of APP/PS1 mice via regulating intestinal flora and its metabolites |
| Boron | 📋 | ✍ | ⛔ | | 39515586 | Boron: An intriguing factor in retarding Alzheimer's progression |
| Buckwheat | 📋 | | ⛔ | | 39019369 | Polysaccharides extracted from common buckwheat (Fagopyrum esculentum) attenuate cognitive impairment via suppressing RAGE/p38/NF-κB signaling and dysbiosis in AlCl3-treated rats |
| Calcium | 📋 | ✍ | ⛔ | | 36369838 | The protective role of interaction between vitamin D, sex hormones and calcium in multiple sclerosis |
| Cannabidiol Oil | 📋 | ✍ | ⛔ | | 31213295 | Therapeutic impact of orally administered cannabinoid oil extracts in an experimental autoimmune encephalomyelitis animal model of multiple sclerosis |
| Casein Protein | 📋 | ✍ | ⛔ | | 34875994 | Lactose and Casein Cause Changes on Biomarkers of Oxidative Damage and Dysbiosis in an Experimental Model of Multiple Sclerosis |
| Cashew | 📋 | | ⛔ | | 34576912 | Cashew Nut Shell Liquid (CNSL) as a Source of Drugs for Alzheimer's Disease |
| Cedarwood Essential Oil | 📋 | ✍ | ⛔ | | 32037737 | Examination of the influence of cedar fragrance on cognitive function and behavioral and psychological symptoms of dementia in Alzheimer type dementia |
| Celery | 📋 | | ⛔ | | 40430359 | Exploring the Neuroprotective Properties of Celery (Apium graveolens Linn) Extract Against Amyloid-Beta Toxicity and Enzymes Associated with Alzheimer's Disease |
| Chamomile | 📋 | ✍ | ⛔ | | 33824100 | Effect of M. chamomilla L. tea on chlorpromazine induced catalepsy: A neuroprotective study |
| Chamomile Essential Oil | 📋 | ✍ | ⛔ | | 38229887 | Biochemical characterization of chamomile essential oil: Antioxidant, antibacterial, anticancer and neuroprotective activity and potential treatment for Alzheimer's disease |
| Chebulinic Acid | 📋 | | | | 37453379 | Inhibition mechanisms of four ellagitannins from terminalia chebula fruits on acetylcholinesterase by inhibition kinetics, spectroscopy and molecular docking analyses |
| Chlorella | 📋 | ✍ | ⛔ | | 37144207 | Exploring the therapeutic efficacy of Chlorella pyrenoidosa peptides in ameliorating Alzheimer's disease |
| Cinnamon Essential Oil | 📋 | ✍ | ⛔ | | 32166553 | Protective effects of Cinnamomum verum, Cinnamomum cassia and cinnamaldehyde against 6-OHDA-induced apoptosis in PC12 cells |
| Clove Essential Oil | 📋 | | ⛔ | | 37119836 | Swimming exercise and clove oil can improve memory by molecular responses modification and reduce dark cells in rat model of Alzheimer's disease |
| Corn Silk | 📋 | ✍ | ⛔ | | 37563784 | Role of corn silk for the treatment of Alzheimer's disease: A mechanism research based on network pharmacology combined with molecular docking and experimental validation |
| Costus | 📋 | ✍ | ⛔ | | 33790692 | Saussureae Radix Attenuates Neuroinflammation in LPS-Stimulated Mouse BV2 Microglia via HO-1/Nrf-2 Induction and Inflammatory Pathway Inhibition |
| Delphinidin | 📋 | | | | 40542425 | Delphinidin attenuates cognitive deficits and pathology of Alzheimer's disease by preventing microglial senescence via AMPK/SIRT1 pathway |
| Docosapentaenoic Acid | 📋 | ✍ | | | 33178186 | The Novel Omega-6 Fatty Acid Docosapentaenoic Acid Positively Modulates Brain Innate Immune Response for Resolving Neuroinflammation at Early and Late Stages of Humanized APOE-Based Alzheimer's Disease Models |
| Eclipta Alba | 📋 | ✍ | | | 33145730 | Neuroprotective effects of hydro-alcoholic extract of Eclipta alba against 1-methyl-4-phenylpyridinium-induced in vitro and in vivo models of Parkinson's disease |
| Egg | 📋 | | ⛔ | | 38782209 | Association of Egg Intake With Alzheimer's Dementia Risk in Older Adults: The Rush Memory and Aging Project |
| Equol | 📋 | ✍ | ⛔ | | 32761299 | Equol, a Blood-Brain Barrier Permeable Gut Microbial Metabolite of Dietary Isoflavone Daidzein, Exhibits Neuroprotective Effects against Neurotoxins Induced Toxicity in Human Neuroblastoma SH-SY5Y Cells and Caenorhabditis elegans |
| Fiber | 📋 | ✍ | ⛔ | | 38142919 | Dietary fibre confers therapeutic effects in a preclinical model of Huntington's disease |
| Fig | 📋 | | ⛔ | | 24938828 | Consumption of fig fruits grown in Oman can improve memory, anxiety, and learning skills in a transgenic mice model of Alzheimer's disease |
| Fufang Danshen | 📋 | | | | 29770796 | Suppression of MIF-induced neuronal apoptosis may underlie the therapeutic effects of effective components of Fufang Danshen in the treatment of Alzheimer's disease |
| Ginger Essential Oil | 📋 | ✍ | | | 38106635 | The preventive effect of Zingiber officinale essential oil on demyelination of corpus callosum in a cuprizone rat model of multiple sclerosis |
| Ginkgetin | 📋 | | | | 29214278 | Ginkgetin Ameliorates Neuropathological Changes in APP/PS1 Transgenical Mice Model |
| Glycyrrhetinic Acid | 📋 | | | | 37436491 | 18β-glycyrrhetinic acid ameliorates MPTP-induced neurotoxicity in mice through activation of microglial anti-inflammatory phenotype |
| Grape Seed Oil | 📋 | | ⛔ | | 32665902 | Grape Seed Oil as a Natural Therapy in Male Rats with Alzheimer's Diseases |
| Honeysuckle | 📋 | | ⛔ | | 39606633 | Revealing the potential therapeutic mechanism of Lonicerae Japonicae Flos in Alzheimer's disease: a computational biology approach |
| Hops | 📋 | ✍ | ⛔ | | 35498911 | Discovery of 8-prenylnaringenin from hop ( Humulus lupulus L.) as a potent monoacylglycerol lipase inhibitor for treatments of neuroinflammation and Alzheimer's disease |
| Horse Chestnut | 📋 | ✍ | ⛔ | | 32158393 | Escins Isolated from Aesculus chinensis Bge. Promote the Autophagic Degradation of Mutant Huntingtin and Inhibit its Induced Apoptosis in HT22 cells |
| Hypericin | 📋 | | | | 37183545 | Hypericin as a potential drug for treating Alzheimer's disease and type 2 diabetes with a view to drug repositioning |
| Inulin | 📋 | ✍ | ⛔ | | 39287045 | Prebiotic inulin controls Th17 cells mediated central nervous system autoimmunity through modulating the gut microbiota and short chain fatty acids |
| Isoquercitrin | 📋 | | | | 34047315 | The neuroprotective effects of isoquercitrin purified from apple pomace by high-speed countercurrent chromatography in the MPTP acute mouse model of Parkinson's disease |
| Jujube | 📋 | | ⛔ | | 35922734 | An aqueous macerate of Ziziphus jujuba reduces long-term spatial memory impairment in D-galactose treated rats: role of anti-inflammatory pathways |
| Kiwifruit | 📋 | ✍ | ⛔ | | 26576196 | Antiamnesic Effect of Actinidia arguta Extract Intake in a Mouse Model of TMT-Induced Learning and Memory Dysfunction |
| Krill Oil | 📋 | ✍ | ⛔ | | 36185487 | Antarctic krill oil exhibited synergistic effects with nobiletin and theanine in ameliorating memory and cognitive deficiency in SAMP8 mice: Applying the perspective of the sea-land combination to retard brain aging |
| L-Citrulline | 📋 | ✍ | ⛔ | | 33940559 | Citrulline supplementation improves spatial memory in a murine model for Alzheimer's disease |
| L-Glutamine | 📋 | ✍ | ⛔ | | 38489176 | Mendelian Randomization of Blood Metabolites Suggests Circulating Glutamine Protects Against Late-Onset Alzheimer's Disease |
| L-Leucine | 📋 | ✍ | ⛔ | | 38382647 | Vcp overexpression and leucine supplementation extend lifespan and ameliorate neuromuscular junction phenotypes of a SOD1G93A-ALS mouse model |
| L-Lysine | 📋 | ✍ | ⛔ | | 21127688 | Could Lysine Supplementation Prevent Alzheimer's Dementia? A Novel Hypothesis |
| Lemon Essential Oil | 📋 | ✍ | ⛔ | | 33052945 | Aromatherapy improves cognitive dysfunction in senescence-accelerated mouse prone 8 by reducing the level of amyloid beta and tau phosphorylation |
| Lemon Verbena | 📋 | | ⛔ | | 25617561 | Effects of dietary supplementation with lemon verbena extracts on serum inflammatory markers of multiple sclerosis patients |
| Lettuce | 📋 | | ⛔ | | 35101010 | In vitro and in vivo evaluations of antioxidative, anti-Alzheimer, antidiabetic and anticancer potentials of hydroponically and soil grown Lactuca sativa |
| Limonin | 📋 | | | | 37536186 | Oral administration of Limonin (LM) exerts neuroprotective effects by inhibiting neuron autophagy and microglial activation in 6-OHDA-injected rats |
| Lingonberry | 📋 | | ⛔ | | 40076984 | Revealing Lingonberry's Neuroprotective Potential in Alzheimer's Disease Through Network Pharmacology and Molecular Docking |
| Loquat | 📋 | ✍ | ⛔ | | 21168467 | Neuroprotective effects of Eriobotrya japonica against β-amyloid-induced oxidative stress and memory impairment |
| Maca Root | 📋 | ✍ | ⛔ | | 38734297 | Neuroprotection of macamide in a mouse model of Alzheimer's disease involves Nrf2 signaling pathway and gut microbiota |
| Magnolia | 📋 | ✍ | ⛔ | | 38955265 | Neolignans in Magnolia officinalis as natural anti-Alzheimer's disease agents: A systematic review |
| Mandarin | 📋 | | | | 33808343 | A Flavonoid-Rich Extract of Mandarin Juice Counteracts 6-OHDA-Induced Oxidative Stress in SH-SY5Y Cells and Modulates Parkinson-Related Genes |
| Mango Leaf | 📋 | | ⛔ | | 27537110 | Mango leaf extract improves central pathology and cognitive impairment in a type 2 diabetes mouse model |
| Marjoram | 📋 | | ⛔ | | 37210483 | Origanum majorana L. protects against neuroinflammation-mediated cognitive impairment: a phyto-pharmacological study |
| Modified Citrus Pectin | 📋 | ✍ | ⛔ | | 39727960 | Assessment of Modified Citrus Pectin's Effects on Dementia in the Scopolamine-Induced Alzheimer's Model in Adult Male Wistar Rats |
| Mustard | 📋 | | ⛔ | | 34856751 | Anti-Parkinson's evaluation of Brassica juncea leaf extract and underlying mechanism of its phytochemicals |
| Myrtle | 📋 | ✍ | ⛔ | | 30553998 | Evaluation of the protective effect of Myrtus communis in scopolamine-induced Alzheimer model through cholinergic receptors |
| Neem | 📋 | ✍ | | | 32477069 | Azadirachta indica A. Juss Ameliorates Mouse Hepatitis Virus-Induced Neuroinflammatory Demyelination by Modulating Cell-to-Cell Fusion in an Experimental Animal Model of Multiple Sclerosis |
| Oak Acorn | 📋 | ✍ | ⛔ | | 39408864 | Extraction Condition Optimization, Quantitative Analysis, and Anti-AD Bioactivity Evaluation of Acorn Polyphenols from Quercus variabilis, Quercus aliena, and Quercus dentata |
| Oats | 📋 | | ⛔ | | 34684684 | Oat Extract Avenanthramide-C Reverses Hippocampal Long-Term Potentiation Decline in Tg2576 Mice |
| Okra | 📋 | | ⛔ | | 37358589 | Abelmoschus esculentus (Okra) Prevents Insulin Resistance and Restores Neuron Autophagy by Regulating Dipeptidyl Peptidase-4 and Thus Improving Hippocampal Function |
| Orange | 📋 | | ⛔ | | 36678510 | Characterization of Orange Peel Extract and Its Potential Protective Effect against Aluminum Chloride-Induced Alzheimer's Disease |
| Orange Essential Oil | 📋 | ✍ | ⛔ | | 33052945 | Aromatherapy improves cognitive dysfunction in senescence-accelerated mouse prone 8 by reducing the level of amyloid beta and tau phosphorylation |
| Oregano | 📋 | ✍ | ⛔ | | 33298273 | Electrochemical screening of genoprotective and antioxidative effectiveness of Origanum vulgare L. and its functionality in the prevention of neurodegenerative disorders |
| Papaya | 📋 | ✍ | ⛔ | | 36451797 | A comparative study of anti-aging effects of Carica papaya (pulp and seeds) on D-galactose-induced brain aging in albino rats |
| Parsnip | 📋 | | ⛔ | | 32700246 | Xanthotoxin reverses Parkinson's disease-like symptoms in zebrafish larvae and mice models: a comparative study |
| Pau d'Arco | 📋 | ✍ | ⛔ | | 35240121 | Antiparkinsonian activity of Tabebuia impetiginosa bark and biochemical analysis of dopamine in rat brain homogenates |
| Peppermint | 📋 | ✍ | ⛔ | | 38625964 | Neuroprotective potential of Mentha piperita extract prevents motor dysfunctions in mouse model of Parkinson's disease through anti-oxidant capacities |
| Peppermint Essential Oil | 📋 | ✍ | ⛔ | | 36986277 | Rosmarinus officinalis and Mentha piperita Oils Supplementation Enhances Memory in a Rat Model of Scopolamine-Induced Alzheimer's Disease-like Condition |
| Phytosterols | 📋 | | | | 34830148 | Phytosterols: Potential Metabolic Modulators in Neurodegenerative Diseases |
| Pine Needle Essential Oil | 📋 | ✍ | ⛔ | | 33655878 | Conifer Essential Oils Reversed Amyloid Beta1-42 Action by Modulating BDNF and ARC Expression in The Rat Hippocampus |
| Pine Nut | 📋 | | ⛔ | | 37821052 | Ameliorative effects of pine nut peptide-zinc chelate (Korean pine) on a mouse model of Alzheimer's disease |
| Piperlongumine | 📋 | | | | 37188283 | Identification of Piperlongumine as Potent Inhibitor of Necroptosis |
| Pomegranate Seed extract | 📋 | | ⛔ | | 35159404 | Punicic Acid and Its Role in the Prevention of Neurological Disorders: A Review |
| Protein | 📋 | ✍ | ⛔ | | 38674911 | Analysis of the Association between Protein Intake and Disability-Adjusted Life Year Rates for Alzheimer's Disease in Japanese Aged over 60 |
| Psyllium | 📋 | ✍ | ⛔ | | 18474374 | The Hydrosoluble Fiber Plantago Ovata Husk Improves Levodopa (With Carbidopa) Bioavailability After Repeated Administration |
| Pumpkin | 📋 | | ⛔ | | 40254703 | Neuroprotective Effects of Cucurbita pepo Extract in Cuprizone-Induced Multiple Sclerosis Animal Model |
| Pumpkin Seed | 📋 | ✍ | ⛔ | | 33759084 | Antiparkinsonian activity of Cucurbita pepo seeds along with possible underlying mechanism |
| Pyridoxal-5-Phosphate | 📋 | ✍ | ⛔ | | 31987026 | An Evaluation of the Effects of Pyridoxal Phosphate in Chlorpromazineinduced Parkinsonism using Mice |
| Retinoic Acid | 📋 | | | | 36598970 | The immunomodulatory effects of all-trans retinoic acid and docosahexaenoic acid combination treatment on the expression of IL-2, IL-4, T-bet, and GATA3 genes in PBMCs of multiple sclerosis patients |
| Rosavin | 📋 | | ⛔ | | 37758932 | Rosavin thwarts amyloid-β-induced macromolecular damages and neurotoxicity, exhibiting anti-Alzheimer's disease activity in Wister rat model |
| Rose | 📋 | | | | 37078068 | Effect of Rosa damascena Extract on Rat Model Alzheimer's Disease: A Histopathological, Behavioral, Enzyme Activities, and Oxidative Stress Study |
| Rosehip | 📋 | ✍ | ⛔ | | 27563424 | Neuroprotective Effects of Herbal Extract (Rosa canina, Tanacetum vulgare and Urtica dioica) on Rat Model of Sporadic Alzheimer's Disease |
| Sage Essential Oil | 📋 | | ⛔ | | 25778348 | Protective properties of Salvia lavandulifolia Vahl. essential oil against oxidative stress-induced neuronal injury |
| Scutellarein | 📋 | | | | 37239029 | A Multilevel Study of Eupatorin and Scutellarein as Anti-Amyloid Agents in Alzheimer's Disease |
| Seafood | 📋 | | | | 36354985 | Marine Sources of DHA-Rich Phospholipids with Anti-Alzheimer Effect |
| Sesame | 📋 | ✍ | ⛔ | | 37539928 | Neuroprotective effects of Sesamum indicum, sesamin and sesamolin against 6-OHDA-induced apoptosis in PC12 cells |
| Sesame Oil | 📋 | | ⛔ | | 33049345 | Sesame oil mitigates memory impairment, oxidative stress, and neurodegeneration in a rat model of Alzheimer's disease. A pivotal role of NF-κB/p38MAPK/BDNF/PPAR-γ pathways |
| Shilajit | 📋 | ✍ | ⛔ | | 37513872 | Scaling the Andean Shilajit: A Novel Neuroprotective Agent for Alzheimer's Disease |
| Spearmint | 📋 | | ⛔ | | 40467024 | Spearmint extract Neumentix downregulates amyloid-β accumulation by promoting phagocytosis in APP23 mice |
| Spearmint Essential Oil | 📋 | ✍ | ⛔ | | 31772594 | Biological Properties and Bioactive Components of Mentha spicata L. Essential Oil: Focus on Potential Benefits in the Treatment of Obesity, Alzheimer's Disease, Dermatophytosis, and Drug-Resistant Infections |
| Star Fuit | 📋 | | ⛔ | | 30196278 | Protective Effects of 2-Dodecyl-6-Methoxycyclohexa-2,5 -Diene-1,4-Dione Isolated from Averrhoa Carambola L. (Oxalidaceae) Roots on Neuron Apoptosis and Memory Deficits in Alzheimer's Disease |
| Sunflower Oil | 📋 | ✍ | ⛔ | | 39973828 | Exploring the mechanism of sunflower seed oil against Alzheimer's disease through experimental and network pharmacology studies |
| Sweet Potato | 📋 | | ⛔ | | 35720655 | Effect of providing purple sweet potato water extract on tumor necrosis factor-α levels, protein 53 expression, glial fibrillary acidic protein expression, brain-derived neurotrophic factor levels, and spatial working memory in rats with d-galactose induction |
| Tamarind | 📋 | | ⛔ | | 35481086 | The anti-Alzheimer potential of Tamarindus indica: an in vivo investigation supported by in vitro and in silico approaches |
| Tea Polyphenols | 📋 | | | | 29495349 | Neuroprotective Effects and Mechanisms of Tea Bioactive Components in Neurodegenerative Diseases |
| Theobromine | 📋 | ✍ | ⛔ | | 27792010 | Theobromine-Induced Changes in A1 Purinergic Receptor Gene Expression and Distribution in a Rat Brain Alzheimer's Disease Model |
| Thyme Essential Oil | 📋 | | ⛔ | | 38688382 | Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell |
| Turkey Tail Mushrooms | 📋 | | ⛔ | | 36289766 | Natural Compounds Such as Hericium erinaceus and Coriolus versicolor Modulate Neuroinflammation, Oxidative Stress and Lipoxin A4 Expression in Rotenone-Induced Parkinson's Disease in Mice |
| Vitamin B Complex | 📋 | | ⛔ | | 40158278 | Combining vinpocetine or cocoa with levodopa, Coenzyme Q10 and vitamin B complex mitigates rotenone-induced Parkinson's disease in rats: Impact on Nrf2/HO-1, NF-kB, AMPK/SIRT-1/Beclin-1, AKT/GSK-3?/CREB/BDNF and Apoptotic Pathways |
| Vitamin K2 mk-7 | 📋 | ✍ | | | 37477796 | Vitamin K2 protects against aluminium chloride-mediated neurodegeneration |
| Whey Protein | 📋 | ✍ | ⛔ | | 37414601 | Whey protein powder with milk fat globule membrane attenuates Alzheimer's disease pathology in 3×Tg-AD mice by modulating neuroinflammation through the peroxisome proliferator-activated receptor γ signaling pathway |
| White Mushrooms | 📋 | | ⛔ | | 36291298 | White Button Mushroom ( Agaricus bisporus) Supplementation Ameliorates Spatial Memory Deficits and Plaque Formation in an Amyloid Precursor Protein Mouse Model of Alzheimer's Disease |
| White Tea | 📋 | | ⛔ | | 21698507 | Neuroprotective effects of white tea against oxidative stress-induced toxicity in striatal cells |
| Wine | 📋 | | ⛔ | | 26092624 | Olive Oil Phenols as Promising Multi-targeting Agents Against Alzheimer's Disease |
| Xylitol | 📋 | ✍ | ⛔ | | 36154609 | Dietary xylitol supplement ameliorated AD related neuronal injury by regulating glucose metabolism relevant amino acids in mice |
| Yerba Mate | 📋 | ✍ | ⛔ | | 40077767 | Yerba Mate (Ilex paraguariensis) Ameliorates Experimental Autoimmune Encephalomyelitis by Modulating Regulatory T Cell Function |
