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List of substances for condition Group: Neurodegenerative Disease

All Human Animal Risk/Association ReviewRows: 509

Substance InfoDose WarnLink PubMed
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Curcumin 📋✍⛔38616356Neuroprotective and anti-inflammatory effects of curcumin in Alzheimer's disease: Targeting neuroinflammation strategies
Cannabidiol 📋✍⛔38654472Cannabidiol attenuates seizure susceptibility and behavioural deficits in adult CDKL5R59X knock-in mice
Vitamin D3 📋✍⛔38636270Diet and omega-3 and vitamin D supplement use predict five-year fatigue and disability trajectories in people with multiple sclerosis
Melatonin 📋✍⛔38561619The Therapeutic Potential of Melatonin in Alzheimer's Disease: A Comprehensive Review
Ginsenosides 📋✍⛔38641079Ginsenoside Rg1 alleviates chronic inflammation-induced neuronal ferroptosis and cognitive impairments via regulation of AIM2 - Nrf2 signaling pathway
Resveratrol 📋✍⛔38504306Unraveling the therapeutic efficacy of resveratrol in Alzheimer's disease: an umbrella review of systematic evidence
EGCG 📋✍⛔38526966Neuroprotective effect of green tea extract (-)-epigallocatechin-3-gallate in a preformed fibril-induced mouse model of Parkinson's disease
Berberine 📋✍⛔38678955Berberine alleviates Alzheimer's disease by regulating the gut microenvironment, restoring the gut barrier and brain-gut axis balance
Quercetin 📋✍⛔38682342Effects of quercetin in preclinical models of Parkinson's disease: A systematic review
Ginkgo Biloba 📋✍⛔38654507Ginkgo biloba and Its Chemical Components in the Management of Alzheimer's Disease
Ginseng 📋✍⛔38707644Emerging evidence that ginseng components improve cognition in subjective memory impairment, mild cognitive impairment, and early Alzheimer's disease dementia
Astaxanthin 📋✍⛔37929718Astaxanthin alleviates ganglioside metabolism disorder in the cortex of Alzheimer's disease mice
CoQ10 📋✍⛔38397789CoQ10 and Mitochondrial Dysfunction in Alzheimer's Disease
Luteolin 📋✍⛔38565590Neuroprotective mechanisms of luteolin in glutamate-induced oxidative stress and autophagy-mediated neuronal cell death
Food 📋 38542790Lower Multiple Sclerosis Severity Score Is Associated with Higher Adherence to Mediterranean Diet in Subjects with Multiple Sclerosis from Northwestern Italy
Baicalein 📋✍⛔38460310Insights into dietary phytochemicals targeting Parkinson's disease key genes and pathways: A network pharmacology approach
Phytochemicals 📋 38471283Development of dietary small molecules as multi-targeting treatment strategies for Alzheimer's disease
Lipoic Acid 📋✍⛔38136170Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia
Vitamin E 📋✍⛔38249609Dietary vitamin E intake and risk of Parkinson's disease: a cross-sectional study
Docosahexaenoic Acid 📋✍⛔38373507N-3 polyunsaturated fatty acids attenuate amyloid-beta-induced toxicity in AD transgenic Caenorhabditis elegans via promotion of proteasomal activity and activation of PPAR-gamma
Genistein 📋✍⛔38275516Epigallocatechin-3-Gallate and Genistein for Decreasing Gut Dysbiosis, Inhibiting Inflammasomes, and Aiding Autophagy in Alzheimer's Disease
Astragalosides 📋✍⛔38412923Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in APP/PS1 mice via inhibition of ferroptosis-lipid peroxidation
Salidroside 📋 38424396Salidroside Mediated the Nrf2/GPX4 Pathway to Attenuates Ferroptosis in Parkinson's Disease
Ginkgolides 📋 38676673[Ginkgolide B: mechanisms of neurobiological effects, prospects for use in the therapy of Alzheimer's disease]
Medicinal Plants 📋 38419106A review on traditional Chinese medicine natural products and acupuncture intervention for Alzheimer's disease based on the neuroinflammatory
Saffron 📋✍⛔38298664Therapeutic effects of saffron and its components on neurodegenerative diseases
Crocin 📋✍⛔38356604Crocin attenuates the lipopolysaccharide-induced neuroinflammation via expression of AIM2 and NLRP1 inflammasome in an experimental model of Parkinson's disease
TUDCA 📋✍⛔38440398Tauroursodeoxycholic acid: a bile acid that may be used for the prevention and treatment of Alzheimer's disease
Vitamin B12 📋✍⛔38700503Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials
Vitamin C 📋✍⛔37537932Therapeutic Potential of Ascorbic Acid in the Management of Alzheimer's Disease: An Update
Acetyl-L-Carnitine 📋✍⛔36998125Acetyl-L-carnitine and Amyotrophic Lateral Sclerosis: current evidence and potential use
Sulforaphane 📋✍⛔37429146Screening of H2S donors with a red emission mitochondria-targetable fluorescent probe: Toward discovering a new therapeutic strategy for Parkinson's disease
Ellagic Acid 📋✍⛔38617645Evaluation of the Binding Mechanism of Dietary Phytochemical, Ellagic Acid, with Human Transferrin: Spectroscopic, Calorimetric, and Computational Approaches Targeting Neurodegenerative Diseases
Icariin 📋✍ 38412923Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in APP/PS1 mice via inhibition of ferroptosis-lipid peroxidation
Naringenin 📋✍⛔37796415Naringenin, a Functional Food Component, Improves Motor and Non-Motor Symptoms in Animal Model of Parkinsonism Induced by Rotenone
Gotu Kola 📋✍⛔37886497Centella asiatica promotes antioxidant gene expression and mitochondrial oxidative respiration in experimental autoimmune encephalomyelitis
Metformin 📋✍⛔38582410The role of the cholinergic system in the memory-protecting effects of metformin in a model of scopolamine-induced memory impairment in aged rats
Omega-3 Fatty Acids 📋✍⛔38678615Omega-3 polyunsaturated fatty acids play a protective role in a mouse model of Parkinson's disease by increasing intestinal inducible Treg cells
Puerarin 📋✍⛔38412923Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in APP/PS1 mice via inhibition of ferroptosis-lipid peroxidation
Rutin 📋✍⛔38256111Effect of the Flavonoid Rutin on the Modulation of the Myenteric Plexuses in an Experimental Model of Parkinson's Disease
Ferulic Acid 📋✍⛔38604452The neuroprotective effects of ferulic acid in toxin-induced models of Parkinson's disease: A review
Nobiletin 📋✍ 37598127The citrus flavonoid "Nobiletin" impedes STZ-induced Alzheimer's disease in a mouse model through regulating autophagy mastered by SIRT1/FoxO3a mechanism
Ashwagandha 📋✍⛔38592845Withania somnifera (L.) Dunal, a Potential Source of Phytochemicals for Treating Neurodegenerative Diseases: A Systematic Review
Hesperidin 📋✍⛔38423185Antioxidant responses driven by Hesperetin and Hesperidin counteract Parkinson's disease-like phenotypes in Drosophila melanogaster
Antioxidants 📋 ⛔38214013Role of oxidative stress in neurodegenerative disorders: a review of reactive oxygen species and prevention by antioxidants
Apigenin 📋✍⛔37038672Effect of apigenin on neurodegenerative diseases
Coconut Oil 📋 ⛔38052316Coconut oil ameliorates behavioral and biochemical alterations induced by D-GAL/AlCl3 in rats
Fisetin 📋✍⛔38671908The Neuroprotective Flavonoids Sterubin and Fisetin Maintain Mitochondrial Health under Oxytotic/Ferroptotic Stress and Improve Bioenergetic Efficiency in HT22 Neuronal Cells
Piperine 📋✍⛔38158101Piperine promotes PI3K/AKT/mTOR-mediated gut-brain autophagy to degrade α-Synuclein in Parkinson's disease rats
Andrographolide 📋 37571363The Effects of Andrographis paniculata (Burm.F.) Wall. Ex Nees and Andrographolide on Neuroinflammation in the Treatment of Neurodegenerative Diseases
Caffeine 📋✍⛔38513162Association of Coffee Consumption and Prediagnostic Caffeine Metabolites With Incident Parkinson Disease in a Population-Based Cohort
Carvacrol 📋✍⛔38649135Neuroprotective role of Carvacrol via Nrf2/HO-1/NLRP3 axis in Rotenone-induced PD mice model
Lycopene 📋✍⛔37320982Lycopene destabilizes preformed Aβ fibrils: Mechanistic insights from all-atom molecular dynamics simulation
Micronutrients 📋 ⛔38623983Comprehensive Insights into Pathophysiology of Alzheimer's Disease: Herbal Approaches for Mitigating Neurodegeneration
Schisandra 📋✍⛔38565361Untargeted metabolomics reveals intervention effects of wine-processed Schisandra chinensis polysaccharide on Alzheimer's disease mice
Nicotinamide Riboside 📋✍⛔38385069The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC derived Cortical Organoid of Alpers' Disease
Goji Berry 📋✍⛔38653878Lycium Barbarum Polysaccharides Improves Cognitive Functions in ICV-STZ-Induced Alzheimer's Disease Mice Model by Improving the Synaptic Structural Plasticity and Regulating IRS1/PI3K/AKT Signaling Pathway
Polyphenols 📋 38490348Dietary polyphenols represent a phytotherapeutic alternative for gut dysbiosis associated neurodegeneration: A Systematic review
Thymoquinone 📋 ⛔38660812Thymoquinone ameliorates symptoms of Parkinson's disease in a 6-OHDA rat model by downregulation of miR-204-3p
Flavonoids 📋 ⛔38039600Dietary flavonoids may have a protective and therapeutic effect in Parkinson disease: A systematic review
Fucoidan 📋✍⛔36876791Fucoidans inhibited tau interaction and cellular uptake
Oleuropein 📋 36774383Oleuropein confers neuroprotection against rotenone-induced model of Parkinson's disease via BDNF/CREB/Akt pathway
Probiotics 📋✍⛔38510467Slowing Alzheimer's disease progression through probiotic supplementation
Reishi Mushrooms 📋✍⛔38720773Ganoderma lucidum spore extract improves sleep disturbances in a rat model of sporadic Alzheimer's disease
Rosmarinic Acid 📋✍ 38703342Rosmarinic acid ameliorated oxidative stress, neuronal injuries, and mitochondrial dysfunctions mediated by polyglutamine and É‘-synuclein in Caenorhabditis elegans models
Selenium 📋✍⛔38136170Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia
Vitamin B9 📋✍⛔38700503Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials
Cinnamon 📋✍⛔37275760Effect of insulin and cinnamon extract on spatial memory and gene expression of GLUT1, 3, and 4 in streptozotocin-induced Alzheimer's model in rats
Naringin 📋✍⛔37526460Pre-clinical Evidence-based Neuroprotective Potential of Naringin against Alzheimer's Disease-like Pathology: A Comprehensive Review
Pomegranate 📋 ⛔38074891A review of pomegranate supplementation: A promising remedial avenue for Alzheimer's disease
Anthocyanins 📋✍⛔37346934Attenuation of amyloid-β-induced mitochondrial dysfunction by active components of anthocyanins in HT22 neuronal cells
Boswellic Acid 📋✍⛔38563150Exploring the immune-modulating properties of boswellic acid in experimental autoimmune encephalomyelitis
Moringa Oleifera 📋✍⛔36686668An insight into the neuroprotective and anti-neuroinflammatory effects and mechanisms of Moringa oleifera
N-Acetyl Cysteine 📋✍⛔37507913Targeting the Cysteine Redox Proteome in Parkinson's Disease: The Role of Glutathione Precursors and Beyond
Olive Polyphenols 📋 36364796Neuroprotective Panel of Olive Polyphenols: Mechanisms of Action, Anti-Demyelination, and Anti-Stroke Properties
Chrysin 📋✍⛔35118868Anti-α-synuclein Toxicity and Anti-neurodegenerative Role of Chrysin in Transgenic Caenorhabditis elegans Models of Parkinson's Disease
Grape Seed extract 📋✍⛔36607588Grape Seed Extract Attenuates Demyelination in Experimental Autoimmune Encephalomyelitis Mice by Inhibiting Inflammatory Response of Immune Cells
Hesperetin 📋 38517352Natural flavonoid hesperetin blocks amyloid β-protein fibrillogenesis, depolymerizes preformed fibrils and alleviates cytotoxicity caused by amyloids
Mangiferin 📋 ⛔38142926Mangiferin alleviates 6-OHDA-induced Parkinson's disease by inhibiting AKR1C3 to activate Wnt signaling pathway
Pterostilbene 📋✍⛔38241160Nicotinamide riboside, pterostilbene and ibudilast protect motor neurons and extend survival in ALS mice
Citicoline 📋✍⛔38136170Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia
Dihydromyricetin 📋✍⛔37712262[Dihydromyricetin alleviates pyroptosis and necroptosis in mice with MPTP-induced chronic Parkinson's disease by inducing autophagy]
Echinacoside 📋 38000105Echinacoside exerts neuroprotection via suppressing microglial α-synuclein/TLR2/NF-κB/NLRP3 axis in parkinsonian models
Fucoxanthin 📋✍⛔36978877The Role of Fucoxanthin as a Potent Nrf2 Activator via Akt/GSK-3β/Fyn Axis against Amyloid-β Peptide-Induced Oxidative Damage
Hydroxytyrosol 📋 37834398The Impact of Hydroxytyrosol on the Metallomic-Profile in an Animal Model of Alzheimer's Disease
NMN 📋✍⛔38504592NAD+ precursor supplementation modulates neurite complexity and survival in motor neurons from ALS models
Olive Oil 📋✍⛔38339193Extra-Virgin Olive Oil in Alzheimer's Disease: A Comprehensive Review of Cellular, Animal, and Clinical Studies
Silymarin 📋✍⛔38353101Adjunctive silymarin supplementation and its effects on disease severity, oxidative stress, and inflammation in patients with Alzheimer's disease
Walnut 📋 ⛔37764868Isolation, Identification, Activity Evaluation, and Mechanism of Action of Neuroprotective Peptides from Walnuts: A Review
Carnosic Acid 📋 36903551Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action
Catechins 📋 36364431Green Tea Catechins Attenuate Neurodegenerative Diseases and Cognitive Deficits
Eicosapentaenoic Acid 📋✍⛔38373507N-3 polyunsaturated fatty acids attenuate amyloid-beta-induced toxicity in AD transgenic Caenorhabditis elegans via promotion of proteasomal activity and activation of PPAR-gamma
Licorice Root 📋✍⛔35307886Metabolomics analysis highlights Yashtimadhu (Glycyrrhiza glabra L.)-mediated neuroprotection in a rotenone-induced cellular model of Parkinson's disease by restoring the mTORC1-AMPK1 axis in autophagic regulation
Silibinin 📋✍ 37480498Oral Administration of Silybin Protects Against MPTP-Induced Neurotoxicity by Reducing Pro-inflammatory Cytokines and Preserving BDNF Levels in Mice
Asiatic Acid 📋 32949562Blood-Brain Barrier Permeability of Asiaticoside, Madecassoside and Asiatic Acid in Porcine Brain Endothelial Cell Model
Ginger 📋✍⛔38397589Screening of Active Substances Regulating Alzheimer's Disease in Ginger and Visualization of the Effectiveness on 6-Gingerol Pathway Targets
Kaempferol 📋✍⛔37874194Kaempferol treatment ameliorates memory impairments in STZ‑induced neurodegeneration by acting on reelin signaling
L-Theanine 📋✍⛔37312698L-Theanine Improves Locomotor Function in a Model of Multiple Sclerosis Mice
Rapamycin 📋✍ 38640155Effect and Mechanism of Rapamycin on Cognitive Deficits in Animal Models of Alzheimer's Disease: A Systematic Review and Meta-analysis of Preclinical Studies
Skullcap 📋✍⛔38645989Network Pharmacology and Molecular Docking Identify the Potential Mechanism and Therapeutic Role of Scutellaria baicalensis in Alzheimer's Disease
Zinc 📋✍⛔38239836Association of antioxidants use with the risk of dementia among community-dwelling adults in the United Kingdom biobank
Asiaticoside 📋 38471370Asiaticoside exerts neuroprotection through targeting NLRP3 inflammasome activation
Baicalin 📋✍⛔38016618Baicalin exerts neuroprotective actions by regulating the Nrf2-NLRP3 axis in toxin-induced models of Parkinson's disease
Bee Venom 📋✍⛔37317907Memory Enhancing and Neurogenesis Activity of Honey Bee Venom in the Symptoms of Amnesia: Using Rats with Amnesia-like Alzheimer's Disease as a Model
Carotenoids 📋✍⛔36480951Natural Carotenoids as Neuroprotective Agents for Alzheimer's Disease: An Evidence-Based Comprehensive Review
Coffee 📋✍⛔38714417Coffee and tea consumption and dementia risk: The role of sex and vascular comorbidities
Gallic Acid 📋 ⛔38549642Gallic Acid Alleviates Cognitive Impairment by Promoting Neurogenesis via the GSK3β-Nrf2 Signaling Pathway in an APP/PS1 Mouse Model
Magnesium 📋✍⛔36613667Magnesium and the Brain: A Focus on Neuroinflammation and Neurodegeneration
Urolithins 📋 37508017Urolithin A in Health and Diseases: Prospects for Parkinson's Disease Management
Aged Garlic 📋✍⛔35805955Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer's Disease
Bacopa Monnieri 📋✍⛔38671841Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis
Bilobalide 📋 36037147Targeting the differentiation of astrocytes by Bilobalide in the treatment of Parkinson's disease model
Dihydroquercetin 📋 38723817Dihydroquercetin alleviates dopamine neuron loss via regulating TREM2 activation
Frankincense 📋✍⛔35804280Methanolic Extract of Boswellia serrata Gum Protects the Nigral Dopaminergic Neurons from Rotenone-Induced Neurotoxicity
Green Tea Polyphenols 📋✍⛔38136170Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia
Mulberry 📋 ⛔38612872Mulberry Leaf Compounds and Gut Microbiota in Alzheimer's Disease and Diabetes: A Study Using Network Pharmacology, Molecular Dynamics Simulation, and Cellular Assays
Mushrooms 📋 ⛔37569241Unveiling the Therapeutic Potentials of Mushroom Bioactive Compounds in Alzheimer's Disease
Myricetin 📋 ⛔38423257Protective Effects of Myricetin and Morin on Neurological Damage in Aβ1-42/Al3+ -induced Alzheimer's Disease Model of Rats
Paeoniflorin 📋 38027768Network pharmacology and in vivo studies reveal the neuroprotective effects of paeoniflorin on Alzheimer's disease
Allicin 📋✍⛔35805955Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer's Disease
Artemisinin 📋 38056239Artemisinin protects dopaminergic neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in a mouse model of Parkinson's disease
Astragalus Root 📋✍⛔37385966Total Flavonoids of Astragalus Inhibit Activated CD4[Formula: see text] T Cells and Regulate Differentiation of Th17/Th1/Treg Cells in Experimental Autoimmune Encephalomyelitis Mice by JAK/STAT and NF[Formula: see text]B Signaling Pathways
Butyrate 📋 ⛔38694925Buty and the beast: the complex role of butyrate in Parkinson's disease
Cocoa 📋✍⛔36009556Cocoa Extract Provides Protection against 6-OHDA Toxicity in SH-SY5Y Dopaminergic Neurons by Targeting PERK
Cordycepin 📋 38479634Neuroprotective effects of cordycepin on MPTP-induced Parkinson's disease mice via suppressing PI3K/AKT/mTOR and MAPK-mediated neuroinflammation
Creatine 📋✍⛔38262563Creatine supplementation with exercise reduces α-synuclein oligomerization and necroptosis in Parkinson's disease mouse model
Emodin 📋 ⛔38405501Neuroprotective, Anti-Inflammatory and Antifibrillogenic Offerings by Emodin against Alzheimer's Dementia: A Systematic Review
Mangosteen 📋✍⛔36552604Mangosteen Pericarp Extract Supplementation Boosts Antioxidant Status via Rebuilding Gut Microbiota to Attenuate Motor Deficit in 6-OHDA-Induced Parkinson's Disease
Morin 📋 38423257Protective Effects of Myricetin and Morin on Neurological Damage in Aβ1-42/Al3+ -induced Alzheimer's Disease Model of Rats
NAD 📋 34928817NAD+ improved experimental autoimmune encephalomyelitis by regulating SIRT1 to inhibit PI3K/Akt/mTOR signaling pathway
Nigella Sativa 📋✍⛔29962349A Review on Possible Therapeutic Effect of Nigella sativa and Thymoquinone in Neurodegenerative Diseases
Ollive Leaf extract 📋✍⛔38136170Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia
Pine Bark 📋✍⛔36153882Pycnogenol® supplementation alleviates symptoms of Parkinson's disease with mild cognitive impairment
Punicalagin 📋✍⛔37896179Punicalagin's Protective Effects on Parkinson's Progression in Socially Isolated and Socialized Rats: Insights into Multifaceted Pathway
Salvianolic Acid 📋 37913602Salvianolic acid B exerts protective effects against Aβ-induced neuroinflammation through the inhibition of NLRP3 inflammasome activation and switching of M1/M2 polarization
Thymol 📋✍⛔36808768Thymol in Trachyspermum ammi seed extract exhibits neuroprotection, learning, and memory enhancement in scopolamine-induced Alzheimer's disease mouse model
Trehalose 📋 ⛔37542649Metformin and Trehalose-Modulated Autophagy Exerts a Neurotherapeutic Effect on Parkinson's Disease
Vitamin A 📋✍⛔37353624Vitamins A and D Enhance the Expression of Ror-γ-Targeting miRNAs in a Mouse Model of Multiple Sclerosis
Withanolides 📋 34680087Effect of Ashwagandha Withanolides on Muscle Cell Differentiation
Bee Propolis 📋✍⛔38583392Preventive effect of propolis on cognitive decline in Alzheimer's disease model mice
Beta-Sitosterol 📋✍⛔38461353Deciphering the effect of phytosterols on Alzheimer's disease and Parkinson's disease: the mediating role of lipid profiles
Blueberry 📋✍⛔37647279Blueberry extracts antagonize Aβ25-35 neurotoxicity and exert a neuroprotective effect through MEK-ERK-BDNF/UCH-L1 signaling pathway in rat and mouse hippocampus
Catalpol 📋 37336148Catalpol rescues cognitive deficits by attenuating amyloid β plaques and neuroinflammation
Chlorogenic Acid 📋✍⛔38069054Antioxidant, Anti-Inflammatory and Pro-Differentiative Effects of Chlorogenic Acid on M03-13 Human Oligodendrocyte-like Cells
Evening Primrose Oil 📋✍⛔36464068Protective effects of evening primrose oil on behavioral activities, nigral microglia and histopathological changes in a rat model of rotenone-induced parkinsonism
Ginger extract 📋✍⛔36029169The effect of Zingiber Officinale Extract on Preventing Demyelination of Corpus Callosum in a Rat Model of Multiple Sclerosis
Green Tea 📋✍⛔36766162Computer-Aided Screening and Revealing Action Mechanism of Green Tea Polyphenols Intervention in Alzheimer's Disease
Honokiol 📋 38327632Effect of Honokiol on culture time and survival of Alzheimer's disease iPSC-derived neurons
Hyperoside 📋 38500281Neuroinflammatory Response and Redox-regulation Activity of Hyperoside in Manganese-induced Neurotoxicity Model of Wistar Rats
Icaritin 📋 37990437Icaritin greatly attenuates β-amyloid-induced toxicity in vivo
L-Carnosine 📋✍⛔35624713Antioxidant and Neuroprotective Effects of Carnosine: Therapeutic Implications in Neurodegenerative Diseases
Lutein 📋✍⛔38487969Lutein and the Underlying Neuroprotective Promise against Neurodegenerative Diseases
Magnolol 📋 37301184Magnolol as STAT3 inhibitor for treating multiple sclerosis by restricting Th17 cells
Schisandrins 📋 36747236Combined with UPLC-Triple-TOF/MS-based plasma lipidomics and molecular pharmacology reveals the mechanisms of schisandrin against Alzheimer's disease
Senolytics 📋 38164616Pharmacological targeting of senescence with senolytics as a new therapeutic strategy for neurodegeneration
Spikenard 📋✍⛔37559448Nardostachys jatamansi and levodopa combination alleviates Parkinson's disease symptoms in rats through activation of Nrf2 and inhibition of NLRP3 signaling pathways
Spirulina 📋✍⛔36861852The effects of spirulina intake on clinical and metabolic parameters in Alzheimer's disease: A randomized, double-blind, controlled trial
Stinging Nettle 📋✍⛔38387425The role of stinging nettle (Urtica dioica L.) in the management of rotenone-induced Parkinson's disease in rats
Tangeretin 📋 38672774An Update on the Potential of Tangeretin in the Management of Neuroinflammation-Mediated Neurodegenerative Disorders
Turmeric 📋✍⛔35674299Neuroprotective potential of curcuminoids in modulating Alzheimer's Disease via multiple signaling pathways
Ursolic Acid 📋✍⛔38337633Dietary Supplementation with 23-Hydroxy Ursolic Acid Reduces the Severity and Incidence of Acute Experimental Autoimmune Encephalomyelitis (EAE) in a Murine Model of Multiple Sclerosis
Vitamin B1 📋✍⛔36543778Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation
Vitamin B7 📋✍⛔38045419Biotin rescues manganese-induced Parkinson's disease phenotypes and neurotoxicity
Vitamin K2 📋✍⛔34199021Vitamin K2 Holds Promise for Alzheimer's Prevention and Treatment
Vitamins 📋 38397800A Combinational Therapy for Preventing and Delaying the Onset of Alzheimer's Disease: A Focus on Probiotic and Vitamin Co-Supplementation
Wormwood 📋✍⛔36999542Mechanism and Molecular Targets of a Water-Soluble Extract of Artemisia annua on the Treatment of Alzheimer's Disease Based on Network Pharmacology and Experimental Validation
Alpha-Linolenic Acid 📋✍⛔37344230Association of Polyunsaturated Fatty Acids and Clinical Progression in Patients With ALS: Post Hoc Analysis of the EMPOWER Trial
Angelica 📋✍⛔35983893Medicine-food herb: Angelica sinensis, a potential therapeutic hope for Alzheimer's disease and related complications
Arctigenin 📋 38104254Arctigenin attenuated spatial memory impairment in pR5 mice by regulating mitochondrial energy metabolism
Beta-Carotene 📋✍⛔36982248β-Carotene, a Potent Amyloid Aggregation Inhibitor, Promotes Disordered Aβ Fibrillar Structure
Black Pepper 📋✍⛔37237954Black Pepper ( Piper nigrum) Alleviates Oxidative Stress, Exerts Potential Anti-Glycation and Anti-AChE Activity: A Multitargeting Neuroprotective Agent against Neurodegenerative Diseases
Capsaicin 📋✍⛔37373321A Systematic Review of the Effects of Capsaicin on Alzheimer's Disease
Choline 📋✍⛔37214864Low circulating choline, a modifiable dietary factor, is associated with the pathological progression and metabolome dysfunction in Alzheimer's disease
Cinnamaldehyde 📋 38621979[Improvement effect of cinnamaldehyde on reserpine-induced Parkinson's disease rat model]
Crocetin 📋 34224829Saffron ameliorated motor symptoms, short life span and retinal degeneration in Parkinson's disease fly models
Eugenol 📋 38215654Eugenol alleviates the symptoms of experimental autoimmune encephalomyelitis in mice by suppressing inflammatory responses
Galangin 📋 36834819Galangin Rescues Alzheimer's Amyloid-β Induced Mitophagy and Brain Organoid Growth Impairment
Ganoderic Acid 📋 37287673Identification of potential neuroprotective compound from Ganoderma lucidum extract targeting microtubule affinity regulation kinase 4 involved in Alzheimer's disease through molecular dynamics simulation and MMGBSA
Garlic 📋✍⛔36861262The Pharmacological Activity of Garlic ( Allium sativum) in Parkinson's Disease: From Molecular Mechanisms to the Therapeutic Potential
Geniposide 📋 37451492Geniposide protects against neurotoxicity in mouse models of rotenone-induced Parkinson's disease involving the mTOR and Nrf2 pathways
Gingerol 📋✍ 38397589Screening of Active Substances Regulating Alzheimer's Disease in Ginger and Visualization of the Effectiveness on 6-Gingerol Pathway Targets
Grape 📋 ⛔36613906Protective Effects of Currants ( Vitis vinifera) on Corticolimbic Serotoninergic Alterations and Anxiety-like Comorbidity in a Rat Model of Parkinson's Disease
Hawthorn 📋✍⛔36447359Neuroprotective effects of hawthorn leaf flavonoids in Aβ25-35 -induced Alzheimer's disease model
Holy Basil 📋✍⛔35900690Amelioration of intracerebroventricular streptozotocin-induced cognitive dysfunction by Ocimum sanctum L. through the modulation of inflammation and GLP-1 levels
Irisin 📋 38658376Research progress on the regulatory mechanisms of Irisin on cognitive dysfunction in patients with Alzheimer's disease and the interventional role of Irisin in associated diseases
Isoliquiritigenin 📋 36484427Isoliquiritigenin inhibits microglia-mediated neuroinflammation in models of Parkinson's disease via JNK/AKT/NFκB signaling pathway
L-Carnitine 📋✍⛔38248238New Insight into the Possible Roles of L-Carnitine in a Rat Model of Multiple Sclerosis
Licochalcones 📋 37762479Licochalcone A: A Potential Multitarget Drug for Alzheimer's Disease Treatment
Lion's Mane Mushrooms 📋✍⛔36289766Natural Compounds Such as Hericium erinaceus and Coriolus versicolor Modulate Neuroinflammation, Oxidative Stress and Lipoxin A4 Expression in Rotenone-Induced Parkinson's Disease in Mice
Pomegranate Peel extract 📋✍⛔35164175Healthy Properties of a New Formulation of Pomegranate-Peel Extract in Mice Suffering from Experimental Autoimmune Encephalomyelitis
St. Johns Wort 📋✍⛔38279301Apolar Extracts of St. John's Wort Alleviate the Effects of β-Amyloid Toxicity in Early Alzheimer's Disease
Stigmasterol 📋 38461353Deciphering the effect of phytosterols on Alzheimer's disease and Parkinson's disease: the mediating role of lipid profiles
Telmisartan 📋 ⛔38419447Telmisartan Protects Mitochondrial Function, Gait, and Neuronal Apoptosis by Activating the Akt/GSK3β/PGC1α Pathway in an MPTP-Induced Mouse Model of Parkinson's Disease
Tetrahydrocurcumin 📋✍ 34679727Tetrahydrocurcumin Has Similar Anti-Amyloid Properties as Curcumin: In Vitro Comparative Structure-Activity Studies
Vitamin B5 📋✍⛔34564384Substantively Lowered Levels of Pantothenic Acid (Vitamin B5) in Several Regions of the Human Brain in Parkinson's Disease Dementia
5-HTP 📋✍⛔369187415-Hydroxytryptophan Reduces Levodopa-Induced Dyskinesia via Regulating AKT/mTOR/S6K and CREB/ΔFosB Signals in a Mouse Model of Parkinson's Disease
Andrographis 📋✍⛔38057817Ethanol extract of Andrographis paniculata alleviates aluminum-induced neurotoxicity and cognitive impairment through regulating the p62-keap1-Nrf2 pathway
Betaine 📋✍⛔37811321Making the case for prophylactic use of betaine to promote brain health in young (15-24 year old) athletes at risk for concussion
Caffeic Acid 📋✍⛔37864768Implication of Caffeic Acid for the Prevention and Treatment of Alzheimer's Disease: Understanding the Binding with Human Transferrin Using In Silico and In Vitro Approaches
CAPE 📋 37313025Caffeic Acid Phenethyl Ester With Mesenchymal Stem Cells Improves Behavioral and Histopathological Changes in the Rat Model of Parkinson Disease
Carnosol 📋 35973126Carnosol Reduced Pathogenic Protein Aggregation and Cognitive Impairment in Neurodegenerative Diseases Models via Improving Proteostasis and Ameliorating Mitochondrial Disorders
Chokeberry 📋✍⛔36978994Plant-Based Antioxidants for Prevention and Treatment of Neurodegenerative Diseases: Phytotherapeutic Potential of Laurus nobilis, Aronia melanocarpa, and Celastrol
Conjugated Linoleic Acid 📋✍⛔38218550Dietary conjugated linoleic acid downregulates the AlCl3-induced hyperactivation of compensatory and maladaptive signalling in the mouse brain cortex
Coptis Chinensis 📋 ⛔38599826Protective Effects of Coptis chinensis Rhizome Extract and Its Constituents (Berberine, Coptisine, and Palmatine) against α-Synuclein Neurotoxicity in Dopaminergic SH-SY5Y Cells
Dioscin 📋 38024855Protective effects of dioscin against Parkinson's disease via regulating bile acid metabolism through remodeling gut microbiome/GLP-1 signaling
Fenugreek 📋✍⛔37231762Pharmacological attributes of Fenugreek with special reference to Alzheimer's disease
Fish Oil 📋✍⛔38348197Fish oil supplementation, physical activity and risk of incident Parkinson's disease: results of longitudinal analysis from the UK Biobank
L-Arginine 📋✍⛔37660966Protective effects of L-arginine on Alzheimer's disease: Modulating hippocampal nitric oxide levels and memory deficits in aluminum chloride-induced rat model
Ligustilide 📋 33111362Ligustilide alleviates neurotoxicity in SH-SY5Y cells induced by Aβ25-35 via regulating endoplasmic reticulum stress and autophagy
Linalool 📋 ⛔38723901Linalool acts as a chemical chaperone by inhibiting amyloid-β aggregation
Lotus 📋 ⛔36757040Procyanidins extracted from the lotus seedpod ameliorate cognitive impairment through CREB-BDNF pathway mediated LTP in APP/PS1 transgenic mice
Nicotinamide 📋✍⛔37663127Nicotinamide enhances myelin production after demyelination through reduction of astrogliosis and microgliosis
Nootkatone 📋 38001852Astrocytic Nrf2 Mediates the Neuroprotective and Anti-Inflammatory Effects of Nootkatone in an MPTP-Induced Parkinson's Disease Mouse Model
PEA 📋✍⛔36139030Palmitoylethanolamide and White Matter Lesions: Evidence for Therapeutic Implications
Peony 📋 ⛔37838295Total Glucosides of White Paeony Capsule ameliorates Parkinson's disease-like behavior in MPTP-induced mice model by regulating LRRK2/alpha-synuclein signaling
Prebiotics 📋✍⛔38495755Gut microbiota and its metabolites in Alzheimer's disease: from pathogenesis to treatment
Rosemary 📋✍⛔38258779Deciphering Neuroprotective Effect of Rosmarinus officinalis L. (syn. Salvia rosmarinus Spenn.) through Preclinical and Clinical Studies
Sesamin 📋✍ 37539928Neuroprotective effects of Sesamum indicum, sesamin and sesamolin against 6-OHDA-induced apoptosis in PC12 cells
Spermidine 📋 38401586Synergistic effect of spermidine and ciprofloxacin against Alzheimer's disease in male rat via ferroptosis modulation
Tanshinone 📋 38659601Tanshinone IIA improves Alzheimer's disease via RNA nuclear-enriched abundant transcript 1/microRNA-291a-3p/member RAS oncogene family Rab22a axis
Taurine 📋✍⛔38548872Taurine reduces microglia activation in the brain of aged senescence-accelerated mice by increasing the level of TREM2
Vitamin B6 📋✍⛔36208656Dietary vitamin B6 restriction aggravates neurodegeneration in mice fed a high-fat diet
Withaferin A 📋 34204308Role of Withaferin A and Its Derivatives in the Management of Alzheimer's Disease: Recent Trends and Future Perspectives
Acai Berry 📋✍⛔37109548Acai Berry ( Euterpe sp.) Extracts Are Neuroprotective against L-Glutamate-Induced Toxicity by Limiting Mitochondrial Dysfunction and Cellular Redox Stress
Asparagus 📋 ⛔36569489Effects of Asparagus officinalis on immune system mediated EAE model of multiple sclerosis
Aspirin 📋 ⛔36846997Aspirin Use and Risk of Alzheimer's Disease: A 2-Sample Mendelian Randomization Study
Basil 📋✍⛔35000160Potential innovation against Alzheimer's disorder: a tricomponent combination of natural antioxidants (vitamin E, quercetin, and basil oil) and the development of its intranasal delivery
Blackberry 📋 ⛔38430352Treatment with Blackberry Extract and Metformin in Sporadic Alzheimer's Disease Model: Impact on Memory, Inflammation, Redox Status, Phosphorylated Tau Protein and Insulin Signaling
Blackcurrant 📋✍⛔35790009Anthocyanin-rich blackcurrant extract improves long-term memory impairment and emotional abnormality in senescence-accelerated mice
Bromelain 📋✍⛔36462588Ameliorative effects of bromelain on aluminum-induced Alzheimer's disease in rats through modulation of TXNIP pathway
Copper 📋✍⛔37800457Fundamental Neurochemistry Review: Copper availability as a potential therapeutic target in progressive supranuclear palsy: Insight from other neurodegenerative diseases
Coumaric acid 📋 37414223p-Coumaric acid attenuates the effects of Aβ42 in vitro and in a Drosophila Alzheimer's disease model
Cyanidin 📋✍ 38705400Cyanidin improves spatial memory and cognition in bisphenol A-induced rat model of Alzheimer's-like neuropathology by restoring canonical Wnt signaling
Dandelion 📋✍⛔35053874Herbal Mixture of Carthamus tinctorius L. Seed and Taraxacum coreanum Attenuates Amyloid Beta-Induced Cognitive Dysfunction In Vivo
Diosmin 📋✍⛔34656609The potential neuroprotective effect of diosmin in rotenone-induced model of Parkinson's disease in rats
Folate 📋✍⛔37735121Features of Plasma Homocysteine, Vitamin B12, and Folate in Parkinson's Disease: An Updated Meta-Analysis
Formononetin 📋 35304289Formononetin attenuates Aβ25-35-induced adhesion molecules in HBMECs via Nrf2 activation
Galangal 📋✍⛔36306920Combination of Alpinia Oxyphylla Fructus and Schisandra Chinensis Fructus Ameliorates Aluminum-induced Alzheimer's Disease via reducing BACE1 Expression
Geraniol 📋 37054939Geraniol improves passive avoidance memory and hippocampal synaptic plasticity deficits in a rat model of Alzheimer's disease
Haritaki 📋✍⛔35696798Autophagy activation by Terminalia chebula Retz. reduce Aβ generation by shifting APP processing toward non-amyloidogenic pathway in APPswe transgenic SH-SY5Y cells
Hemp Oil 📋✍⛔30936931Regulatory effects of hemp seed/evening primrose oil supplement in comparison with rapamycin on the expression of the mammalian target of rapamycin-complex 2 and interleukin-10 genes in experimental autoimmune encephalomyelitis
Indian Gooseberry 📋 ⛔38030098Aqueous leaf extract of Phyllanthus amarus protects against oxidative stress and misfiring of dopaminergic neurons in Paraquat-induced Parkinson's disease-like model of adult Wistar rats
Lavender Essential Oil 📋✍⛔33305625Comparing the effects of vestibular rehabilitation with and without lavender oil scents as an olfactory stimulus on balance, fear of falling down and activities of daily living of people with multiple sclerosis: a randomized clinical trial
Liquiritigenin 📋 33965487Exploring the inhibitory effects of liquiritigenin against tau fibrillation and related neurotoxicity as a model of preventive care in Alzheimer's disease
Mucuna Pruriens 📋✍⛔35630617Mucuna pruriens Seed Aqueous Extract Improved Neuroprotective and Acetylcholinesterase Inhibitory Effects Compared with Synthetic L-Dopa
Neferine 📋 37921051Neferine exerts anti‑inflammatory activity in BV‑2 microglial cells and protects mice with MPTP‑induced Parkinson's disease by inhibiting NF‑κB activation
Paeonol 📋 35001353Paeonol Ameliorates Cuprizone-Induced Hippocampal Demyelination and Cognitive Deficits through Inhibition of Oxidative and Inflammatory Events
Persimmon 📋 ⛔34205542Immature Persimmon Suppresses Amyloid Beta (Aβ) Mediated Cognitive Dysfunction via Tau Pathology in ICR Mice
Phytoestrogens 📋 ⛔37673213Diet-microbiome-immune interplay in multiple sclerosis: Understanding the impact of phytoestrogen metabolizing gut bacteria
Plum 📋 ⛔30577585Potential Application of Prunus armeniaca L. and P. domestica L. Leaf Essential Oils as Antioxidant and of Cholinesterases Inhibitors
PQQ 📋✍⛔38454653Deep Learning-Driven Exploration of Pyrroloquinoline Quinone Neuroprotective Activity in Alzheimer's Disease
Procyanidins 📋 ⛔34770830Neuroprotective Effects of B-Type Cinnamon Procyanidin Oligomers on MPP +-Induced Apoptosis in a Cell Culture Model of Parkinson's Disease
Progesterone 📋✍⛔37190115Progesterone: A Neuroprotective Steroid of the Intestine
Red Sage 📋✍⛔34217797Alleviatory effects of Danshen, Salvianolic acid A and Salvianolic acid B on PC12 neuronal cells and Drosophila melanogaster model of Alzheimer's disease
Roselle 📋✍⛔35159249A Distinct Hibiscus sabdariffa Extract Prevents Iron Neurotoxicity, a Driver of Multiple Sclerosis Pathology
Royal Jelly 📋✍⛔36809522Royal jelly improves learning and memory deficits in an amyloid β-induced model of Alzheimer's disease in male rats: Involvement of oxidative stress
Spices 📋 34279199Effects of Spices (Saffron, Rosemary, Cinnamon, Turmeric and Ginger) in Alzheimer's Disease
Tannic Acid 📋✍⛔37712018A natural polyphenol activates and enhances GPX4 to mitigate amyloid-β induced ferroptosis in Alzheimer's disease
Tea 📋 38714417Coffee and tea consumption and dementia risk: The role of sex and vascular comorbidities
UDCA 📋✍⛔38024855Protective effects of dioscin against Parkinson's disease via regulating bile acid metabolism through remodeling gut microbiome/GLP-1 signaling
Zeaxanthin 📋✍⛔35034906Zeaxanthin Attenuates the Vicious Circle Between Endoplasmic Reticulum Stress and Tau Phosphorylation: Involvement of GSK-3β Activation
Acacetin 📋 36382256Acacetin improves cognitive function of APP/PS1 Alzheimer's disease model mice via the NLRP3 inflammasome signaling pathway
Aloe Vera 📋✍⛔35807891Involvement of the Intestinal Microbiota in the Appearance of Multiple Sclerosis: Aloe vera and Citrus bergamia as Potential Candidates for Intestinal Health
Anethole 📋 37972114Anethole attenuates motor dysfunctions, striatal neuronal activity deficiency and blood brain barrier permeability by decreasing striatal α-synuclein and oxidative stress in rotenone-induced Parkinson's disease of male rats
Apple Vinegar 📋✍⛔34323669Neuroprotective Efficacy of Apple Cider Vinegar on Zinc-High Fat Diet-Induced Mono Amine Oxidase Alteration in Murine Model of AD
Asafoetida 📋✍⛔36857494Acetylcholinesterase inhibitory activity of Ferula plants and their potential for treatment of Alzheimer's disease
Atractylodes 📋✍⛔36164880[Mechanism of Atractylodes macrocephala against Alzheimer's disease via regulating lysophagy based on LKB1-AMPK-TFEB pathway]
Bergamot 📋✍⛔35807891Involvement of the Intestinal Microbiota in the Appearance of Multiple Sclerosis: Aloe vera and Citrus bergamia as Potential Candidates for Intestinal Health
Berries 📋 29401686Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effects
Bilberry 📋✍⛔32003387Bilberry anthocyanins improve neuroinflammation and cognitive dysfunction in APP/PSEN1 mice via the CD33/TREM2/TYROBP signaling pathway in microglia
Biochanin A 📋 37039995Neuroprotective potential of biochanin-A and review of the molecular mechanisms involved
Boric Acid 📋✍⛔37220543Therapeutic Efficacy of Boric Acid Treatment on Brain Tissue and Cognitive Functions in Rats with Experimental Alzheimer's Disease
Calycosin 📋 36195188Calycosin ameliorates advanced glycation end product-induced neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer's disease
Chicoric Acid 📋 38542381Chicoric Acid Ameliorated Beta-Amyloid Pathology and Enhanced Expression of Synaptic-Function-Related Markers via L1CAM in Alzheimer's Disease Models
Clove 📋 ⛔37851769Neuroprotective effects of a combination of Boswellia papyrifera and Syzygium aromaticum on AlCl3 induced Alzheimer's disease in male albino rat
Coconut 📋 ⛔29188860A Keto-Mediet Approach with Coconut Substitution and Exercise May Delay the Onset of Alzheimer's Disease among Middle-Aged
Cordyceps 📋✍⛔34936310Caterpillar Medicinal Mushroom, Cordyceps militaris (Ascomycota), Attenuates Aβ1-42-Induced Amyloidogenesis and Inflammatory Response by Suppressing Amyloid Precursor Protein Progression and p38 MAPK/JNK Activation
Coriander 📋 ⛔35922685Heated Leaf Extract of Coriandrum sativum L. Protects Nigral Dopaminergic Degeneration in Rats
Coriander Essential Oil 📋✍⛔32785956Lavender and coriander essential oils and their main component linalool exert a protective effect against amyloid-β neurotoxicity
Cornus 📋 37393274Neuroprotective effects of morroniside from Cornus officinalis sieb. Et zucc against Parkinson's disease via inhibiting oxidative stress and ferroptosis
Daidzein 📋✍⛔38679467Daidzein ameliorates nonmotor symptoms of manganese-induced Parkinsonism in zebrafish model: Behavioural and biochemical approach
Date 📋 ⛔36654869Effects of Phoenix dactylifera against Streptozotocin-Aluminium Chloride Induced Alzheimer's Rats and Their In Silico Study
Diosgenin 📋 37085711Diosgenin restores memory function via SPARC-driven axonal growth from the hippocampus to the PFC in Alzheimer's disease model mice
Diosmetin 📋 35958986Effect of Date Palm ( Phoenix dactylifera) Phytochemicals on Aβ 1-40 Amyloid Formation: An in-silico Analysis
Essential Oils 📋 ⛔38132330Essential Oil Molecules Can Break the Loop of Oxidative Stress in Neurodegenerative Diseases
Eucommia 📋✍⛔35754707Eucommia ulmoides Olive Male Flower Extracts Ameliorate Alzheimer's Disease-Like Pathology in Zebrafish via Regulating Autophagy, Acetylcholinesterase, and the Dopamine Transporter
Fo-Ti Root 📋✍⛔314829002,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside attenuates MPP+/MPTP-induced neurotoxicity in vitro and in vivo by restoring the BDNF-TrkB and FGF2-Akt signaling axis and inhibition of apoptosis
Forskolin 📋✍⛔36614135Intranasal Administration of Forskolin and Noopept Reverses Parkinsonian Pathology in PINK1 Knockout Rats
Gardenia 📋 ⛔38000495Gardenia jasminoides J. Ellis extract attenuates memory impairment in rats with Alzheimer's disease by suppressing NLRP3 inflammasome
Genipin 📋 37865990Genipin and pyrogallol: Two natural small molecules targeting the modulation of disordered proteins in Alzheimer's disease
Guggulsterone 📋 38170440Guggulsterone Selectively Modulates STAT-3, mTOR, and PPAR-Gamma Signaling in a Methylmercury-Exposed Experimental Neurotoxicity: Evidence from CSF, Blood Plasma, and Brain Samples
Hazelnut 📋 ⛔38151890Does hazelnut consumption affect brain health and function against neurodegenerative diseases?
HMB 📋✍⛔38419348Muscle-building supplement β-hydroxy β-methylbutyrate stimulates the maturation of oligodendroglial progenitor cells to oligodendrocytes
Kudzu Root 📋✍⛔33433542In silico-determined compound from the root of Pueraria lobate alleviates synaptic plasticity injury induced by Alzheimer's disease via the p38MAPK-CREB signaling pathway
Lemon Balm 📋✍⛔33122694Safety and efficacy of Melissa officinalis extract containing rosmarinic acid in the prevention of Alzheimer's disease progression
Linoleic Acid 📋✍⛔35892594Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson's Disease: The Implication of Lipid Droplets and Lipophagy
Lychee 📋 ⛔31917277Polyphenols isolated from lychee seed inhibit Alzheimer's disease-associated Tau through improving insulin resistance via the IRS-1/PI3K/Akt/GSK-3β pathway
Madecassoside 📋 38181970Protective role of madecassoside from Centella asiatica against protein L-isoaspartyl methyltransferase deficiency-induced neurodegeneration
Nutmeg 📋✍⛔35662922Inhibitory Effects of Macelignan on Tau Phosphorylation and Aβ Aggregation in the Cell Model of Alzheimer's Disease
Patchouli 📋✍⛔36717922Patchouli alcohol attenuates the cognitive deficits in a transgenic mouse model of Alzheimer's disease via modulating neuropathology and gut microbiota through suppressing C/EBPβ/AEP pathway
Pelargonidin 📋 35694918Pelargonidin and Berry Intake Association with Alzheimer's Disease Neuropathology: A Community-Based Study
Pregnenolone 📋✍⛔36878398Pregnenolone for the treatment of L-DOPA-induced dyskinesia in Parkinson's disease
Pu-erh Tea 📋✍⛔32992081Pu'er tea water extract protects against cognitive impairment in a mouse model of lipopolysaccharide-induced neuroinflammation
PUFA 📋 16679766Polyunsaturated fatty acid supplementation stimulates differentiation of oligodendroglia cells
Rehmannia 📋✍⛔35784741Neuroprotective Effects of Oligosaccharides in Rehmanniae Radix on Transgenic Caenorhabditis elegans Models for Alzheimer's Disease
Rosemary Essential Oil 📋✍⛔36986277Rosmarinus officinalis and Mentha piperita Oils Supplementation Enhances Memory in a Rat Model of Scopolamine-Induced Alzheimer's Disease-like Condition
Safranal 📋 38683404Safranal exerts a neuroprotective effect on Parkinson's disease with suppression of NLRP3 inflammation activation
Sage 📋✍⛔35137748Insights into the neuroprotective effects of Salvia officinalis L. and Salvia microphylla Kunth in the memory impairment rat model
Sea Buckthorn 📋✍⛔37132070Polysaccharides from sea buckthorn (Hippophae rhamnoides L.) berries ameliorates cognitive dysfunction in AD mice induced by a combination of D-gal and AlCl3 by suppressing oxidative stress and inflammation reaction
Seaweeds 📋 ⛔37447330Activation of Liver X Receptors and Peroxisome Proliferator-Activated Receptors by Lipid Extracts of Brown Seaweeds: A Potential Application in Alzheimer's Disease?
Sesamol 📋 34669408Sesamol Attenuates Amyloid Peptide Accumulation and Cognitive Deficits in APP/PS1 Mice: The Mediating Role of the Gut-Brain Axis
Soy 📋✍⛔35634410Effect of Fermentation on the Bioactive Compounds of the Black Soybean and Their Anti-Alzheimer's Activity
Strawberry 📋✍⛔33547659Strawberry (Fragaria ananassa duch.) Alba extract attenuates DNA damage in lymphocytes of patients with Alzheimer's disease
Tribulus Terrestris 📋✍⛔33043200Anti-Parkinson's Activity of Tribulus terrestris via Modulation of AChE, α-Synuclein, TNF-α, and IL-1β
Valerian Root 📋✍⛔31909290"Effect of valerenic acid on neuroinflammation in a MPTP-induced mouse model of Parkinson's disease"
Vitamin B3 📋✍⛔34220485Niacin Enhancement for Parkinson's Disease: An Effectiveness Trial
Wogonin 📋✍⛔33147823Neuroprotective Effects of Baicalein, Wogonin, and Oroxylin A on Amyloid Beta-Induced Toxicity via NF-κB/MAPK Pathway Modulation
Aloe-Emodin 📋 37191091Neuroprotective effect of aloe emodin against Huntington's disease-like symptoms in R6/1 transgenic mice
Apple 📋 ⛔31837654Neuroprotective Effects of Apple-Derived Drinks in a Mice Model of Inflammation
Balloon Flower 📋✍⛔34943071Crude Saponin from Platycodon grandiflorum Attenuates Aβ-Induced Neurotoxicity via Antioxidant, Anti-Inflammatory and Anti-Apoptotic Signaling Pathways
Barberry 📋✍⛔36186093Neuroprotective Effect of Root Extracts of Berberis Vulgaris (Barberry) on Oxidative Stress on SH-SY5Y Cells
Basil Essential Oil 📋✍⛔31997265Ocimum basilicum attenuates ethidium bromide-induced cognitive deficits and pre-frontal cortical neuroinflammation, astrogliosis and mitochondrial dysfunction in rats
Bay Leaf 📋 ⛔36978994Plant-Based Antioxidants for Prevention and Treatment of Neurodegenerative Diseases: Phytotherapeutic Potential of Laurus nobilis, Aronia melanocarpa, and Celastrol
Beta-Lapachone 📋 30739428Neuroprotective Effect of β-Lapachone in MPTP-Induced Parkinson's Disease Mouse Model: Involvement of Astroglial p-AMPK/Nrf2/HO-1 Signaling Pathways
Betulinic Acid 📋 36474564The effects of betulinic acid chronic administration on the motor, non-motor behaviors, and globus pallidus local field potential power in a rat model of hemiparkinsonism
Bitter Melon 📋✍⛔36902074The Effects of Momordica charantia on Type 2 Diabetes Mellitus and Alzheimer's Disease
Bitter Orange 📋✍⛔38078339Activity of Citrus aurantium and Lavandula angustifolia in Alzheimer's Disease Symptoms in Male Wistar Rats
Black Tea 📋✍⛔22138428Theaflavin, a black tea polyphenol, protects nigral dopaminergic neurons against chronic MPTP/probenecid induced Parkinson's disease
Cat's Claw 📋✍⛔38310572Comprehensive In Silico Analysis of Uncaria Tomentosa Extract: Chemical Profiling, Antioxidant Assessment, and CLASP Protein Interaction for Drug Design in Neurodegenerative Diseases
Chaga Mushrooms 📋✍⛔38053824Raw Inonotus obliquus polysaccharide counteracts Alzheimer's disease in a transgenic mouse model by activating the ubiquitin-proteosome system
Cherry 📋 ⛔27578256Tart cherry supplementation improves working memory, hippocampal inflammation, and autophagy in aged rats
Cinnamic Acid 📋 33662757A review on ferulic acid and analogs based scaffolds for the management of Alzheimer's disease
Cranberry 📋✍⛔35631155Neuroprotective Effects of Cranberry Juice Treatment in a Rat Model of Parkinson's Disease
Cryptotanshinone 📋 36124540Cryptotanshinone protects against oxidative stress in the paraquat-induced Parkinson's disease model
D-Mannose 📋✍⛔34814011Oral D-mannose treatment suppresses experimental autoimmune encephalomyelitis via induction of regulatory T cells
Elderberry 📋✍⛔33745925Elderberry diet ameliorates motor function and prevents oxidative stress-induced cell death in rat models of Huntington disease
Escin 📋✍⛔24788336Escin, a novel triterpene, mitigates chronic MPTP/p-induced dopaminergic toxicity by attenuating mitochondrial dysfunction, oxidative stress, and apoptosis
Fermented Foods 📋 ⛔37967591Does a pickle a day keep Alzheimer's away? Fermented food in Alzheimer's disease: A review
Fruits 📋 38347678Causal association between plant foods intake and Alzheimer's disease: a Mendelian randomization study
GABA 📋✍⛔36734072The molecular mechanism of γ-aminobutyric acid against AD: the role of CEBPα/circAPLP2/miR-671-5p in regulating CNTN1/2 expression
Gamma-Linolenic Acid 📋✍⛔16679766Polyunsaturated fatty acid supplementation stimulates differentiation of oligodendroglia cells
Geranium 📋 37819493Therapeutic Effects of Geranium Oil in MPTP-Induced Parkinsonian Mouse Model
Giloy 📋✍⛔37579290Neuroprotective Effects of Tinospora cordifolia via Reducing the Oxidative Stress and Mitochondrial Dysfunction against Rotenone-Induced PD Mice
Glutathione 📋✍⛔35310529Olive polyphenols and bioavailable glutathione: Promising results in patients diagnosed with mild Alzheimer's disease
Glycyrrhizic Acid 📋✍⛔35358621Co-treatment with natural HMGB1 inhibitor Glycyrrhizin exerts neuroprotection and reverses Parkinson's disease like pathology in Zebrafish
Honey 📋✍⛔37570596Apitherapy in Post-Ischemic Brain Neurodegeneration of Alzheimer's Disease Proteinopathy: Focus on Honey and Its Flavonoids and Phenolic Acids
Horny Goat Weed 📋✍⛔35165207The neuroprotective effects of icariin on ageing, various neurological, neuropsychiatric disorders, and brain injury induced by radiation exposure
Indian Mulberry 📋✍⛔36158563Neuroprotective effects of Morinda officinalis How.: Anti-inflammatory and antioxidant roles in Alzheimer's disease
Isoflavones 📋✍⛔34751296Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson's disease models
L-Methionine 📋✍⛔34573099L-Methionine Protects against Oxidative Stress and Mitochondrial Dysfunction in an In Vitro Model of Parkinson's Disease
L-Tryptophan 📋✍⛔34105899Tryptophan in the diet ameliorates motor deficits in a rotenone-induced rat Parkinson's disease model via activating the aromatic hydrocarbon receptor pathway
Lactobacillus plantarum 📋 ⛔38474254Lactiplantibacillus (Lactobacillus) plantarum as a Complementary Treatment to Improve Symptomatology in Neurodegenerative Disease: A Systematic Review of Open Access Literature
Lauric Acid 📋✍ 32863249Lauric acid: Its role in behavioral modulation, neuro-inflammatory and oxidative stress markers in haloperidol induced Parkinson's disease
Lavender 📋✍⛔38078339Activity of Citrus aurantium and Lavandula angustifolia in Alzheimer's Disease Symptoms in Male Wistar Rats
Liquiritin 📋 27589374Neuroprotective effects of liquiritin on cognitive deficits induced by soluble amyloid-β 1-42 oligomers injected into the hippocampus
Long Pepper 📋 ⛔26232071Protection effect of piperine and piperlonguminine from Piper longum L. alkaloids against rotenone-induced neuronal injury
Marigold 📋✍⛔38268908Active compounds from Calendula officinalis flowers act via PI3K and ERK signaling pathways to offer neuroprotective effects against Parkinson's disease
Nattokinase 📋✍⛔37263404Nattokinase prevents β-amyloid peptide (Aβ1-42) induced neuropsychiatric complications, neuroinflammation and BDNF signalling disruption in mice
Neohesperidin 📋 38226659Orally administered neohesperidin attenuates MPTP-induced neurodegeneration by inhibiting inflammatory responses and regulating intestinal flora in mice
Oleanolic Acid 📋 35311613Oleanolic acid and ursolic acid: therapeutic potential in neurodegenerative diseases, neuropsychiatric diseases and other brain disorders
Omega-6 Fatty Acids 📋✍⛔37445890DHA/EPA (Omega-3) and LA/GLA (Omega-6) as Bioactive Molecules in Neurodegenerative Diseases
Onion 📋✍⛔38688382Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell
Oolong Tea 📋 ⛔35629970Metabolomics Study Suggests the Mechanism of Different Types of Tieguanyin (Oolong) Tea in Alleviating Alzheimer's Disease in APP/PS1 Transgenic Mice
Oregano Essential Oil 📋✍⛔35201555A multi-parameter evaluation of the neuroprotective and cognitive-enhancing effects of Origanum onites L. (Turkish Oregano) essential oil on scopolamine-induced amnestic rats
Pantethine 📋✍⛔37194410Pantethine ameliorates recognition impairment in a mouse model of Alzheimer's disease by modulating cholesterol content and intestinal flora species
Parthenolide 📋 37992573Parthenolide alleviates cognitive dysfunction and neurotoxicity via regulation of AMPK/GSK3β(Ser9)/Nrf2 signaling pathway
Phloretin 📋 36463449Neuroprotective Effect of Phloretin in Rotenone-Induced Mice Model of Parkinson's Disease: Modulating mTOR-NRF2-p62 Mediated Autophagy-Oxidative Stress Crosstalk
Phosphatidylserine 📋✍⛔35992593Phosphatidylserine, inflammation, and central nervous system diseases
Polydatin 📋✍ 35479435The polyphenolic phytoalexin polydatin inhibits amyloid aggregation of recombinant human prion protein
Quercitrin 📋 36292931The Flavonol Quercitrin Hinders GSK3 Activity and Potentiates the Wnt/β-Catenin Signaling Pathway
Raspberry 📋✍⛔30397021Identification and Microbial Production of the Raspberry Phenol Salidroside that Is Active against Huntington's Disease
Rhodiola 📋✍⛔32058218Amelioration of experimental autoimmune encephalomyelitis by Rhodiola rosea, a natural adaptogen
Rose Essential Oil 📋 38688895A comprehensive assessment of the cholinergic-supporting and cognitive-enhancing effects of Rosa damascena Mill. (Damask rose) essential oil on scopolamine-induced amnestic rats
Safflower 📋✍⛔35940347Preventive effects of a standardized flavonoid extract of safflower in rotenone-induced Parkinson's disease rat model
SAMe 📋✍⛔32925070S-Adenosylmethionine Rescues Cognitive Deficits in the rTg4510 Animal Model by Stabilizing Protein Phosphatase 2A and Reducing Phosphorylated Tau
Serrapeptase 📋✍⛔35694981The potential of lumbrokinase and serratiopeptidase for the degradation of Aβ 1-42 peptide - an in vitro and in silico approach
Sirtuin Activators 📋 36306110SIRT1 activation and its circadian clock control: a promising approach against (frailty in) neurodegenerative disorders
Syringic Acid 📋 34599991Syringic acid demonstrates promising protective effect against tau fibrillization and cytotoxicity through regulation of endoplasmic reticulum stress-mediated pathway as a prelude to Alzheimer's disease
Theaflavins 📋✍ 22634505Theaflavin ameliorates behavioral deficits, biochemical indices and monoamine transporters expression against subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson's disease
Vitamin B2 📋✍⛔29085589Update on riboflavin and multiple sclerosis: a systematic review
Vitamin K 📋✍⛔38621744The Role of Vitamin K in the Development of Neurodegenerative Diseases
Vitex 📋✍⛔35268709In Vivo Assessment of the Ameliorative Impact of Some Medicinal Plant Extracts on Lipopolysaccharide-Induced Multiple Sclerosis in Wistar Rats
Vitexin 📋 37102042Beneficial Role of Vitexin in Parkinson's Disease
Almond 📋 ⛔29208493Almond, hazelnut and walnut, three nuts for neuroprotection in Alzheimer's disease: A neuropharmacological review of their bioactive constituents
Aloin 📋 35421539Structural and mechanistic insights into modulation of α-Synuclein fibril formation by aloin and emodin
Alpha GPC 📋✍⛔38595916Pharmacological enhancement of cholinergic neurotransmission alleviates neuroinflammation and improves functional outcomes in a triple transgenic mouse model of Alzheimer's disease
Amino Acids 📋 35471671The potential roles of amino acids and their major derivatives in the management of multiple sclerosis
Anthocyanidins 📋 31847371Association of Strawberries and Anthocyanidin Intake with Alzheimer's Dementia Risk
Apple Polyphenols 📋 ⛔33466604Annurca Apple Polyphenol Extract Affects Acetyl- Cholinesterase and Mono-Amine Oxidase In Vitro Enzyme Activity
Apricot 📋 ⛔36212969Pharmacological Potential of the Standardized Methanolic Extract of Prunus armeniaca L. in the Haloperidol-Induced Parkinsonism Rat Model
Arachidonic Acid 📋✍⛔33803760Docosahexaenoic and Arachidonic Acids as Neuroprotective Nutrients throughout the Life Cycle
Argan Oil 📋✍⛔29065513Argan Oil-Mediated Attenuation of Organelle Dysfunction, Oxidative Stress and Cell Death Induced by 7-Ketocholesterol in Murine Oligodendrocytes 158N
Ashitaba 📋✍⛔37403256The neuroprotective effects of Chalcones from Ashitaba on cuprizone-induced demyelination via modulation of brain-derived neurotrophic factor and tumor necrosis factor α
Astragalin 📋 36681681Neuroprotective effect of astragalin via activating PI3K/Akt-mTOR-mediated autophagy on APP/PS1 mice
Avocado 📋✍⛔27651262Avocado as a Major Dietary Source of Antioxidants and Its Preventive Role in Neurodegenerative Diseases
Bamboo 📋✍⛔38334213The alleviative effects comparison of four flavonoids from bamboo leaves on ulcerative colitis in an Alzheimer mouse model
Beets 📋✍⛔33054666Beetroot supplemented diet exhibit anti-amnesic effect via modulation of cholinesterases, purinergic enzymes, monoamine oxidase and attenuation of redox imbalance in the brain of scopolamine treated male rats
Beta-Glucan 📋✍⛔36890624β-Glucan attenuates cognitive impairment of APP/PS1 mice via regulating intestinal flora and its metabolites
Black Ginger 📋✍⛔36904098Kaempferia parviflora Extracts Protect Neural Stem Cells from Amyloid Peptide-Mediated Inflammation in Co-Culture Model with Microglia
Calcium 📋✍⛔36369838The protective role of interaction between vitamin D, sex hormones and calcium in multiple sclerosis
Cannabidiol Oil 📋✍⛔31213295Therapeutic impact of orally administered cannabinoid oil extracts in an experimental autoimmune encephalomyelitis animal model of multiple sclerosis
Cardamom 📋✍⛔31114535Neuroprotective Effect of Cardamom Oil Against Aluminum Induced Neurotoxicity in Rats
Cardamonin 📋 36672126The Neuroprotective Effects and Therapeutic Potential of the Chalcone Cardamonin for Alzheimer's Disease
Casein Protein 📋✍⛔34875994Lactose and Casein Cause Changes on Biomarkers of Oxidative Damage and Dysbiosis in an Experimental Model of Multiple Sclerosis
Cashew 📋 ⛔34576912Cashew Nut Shell Liquid (CNSL) as a Source of Drugs for Alzheimer's Disease
Cedarwood Essential Oil 📋✍⛔32037737Examination of the influence of cedar fragrance on cognitive function and behavioral and psychological symptoms of dementia in Alzheimer type dementia
Chamomile 📋✍⛔33824100Effect of M. chamomilla L. tea on chlorpromazine induced catalepsy: A neuroprotective study
Chamomile Essential Oil 📋✍⛔38229887Biochemical characterization of chamomile essential oil: Antioxidant, antibacterial, anticancer and neuroprotective activity and potential treatment for Alzheimer's disease
Chebulinic Acid 📋 37453379Inhibition mechanisms of four ellagitannins from terminalia chebula fruits on acetylcholinesterase by inhibition kinetics, spectroscopy and molecular docking analyses
Chlorella 📋✍⛔37144207Exploring the therapeutic efficacy of Chlorella pyrenoidosa peptides in ameliorating Alzheimer's disease
Cinnamon Essential Oil 📋✍⛔32166553Protective effects of Cinnamomum verum, Cinnamomum cassia and cinnamaldehyde against 6-OHDA-induced apoptosis in PC12 cells
Clove Essential Oil 📋 ⛔37119836Swimming exercise and clove oil can improve memory by molecular responses modification and reduce dark cells in rat model of Alzheimer's disease
Corn Silk 📋✍⛔37563784Role of corn silk for the treatment of Alzheimer's disease: A mechanism research based on network pharmacology combined with molecular docking and experimental validation
Costus 📋✍⛔33790692Saussureae Radix Attenuates Neuroinflammation in LPS-Stimulated Mouse BV2 Microglia via HO-1/Nrf-2 Induction and Inflammatory Pathway Inhibition
DHEA 📋✍⛔28707358Suppressed oligodendrocyte steroidogenesis in multiple sclerosis: Implications for regulation of neuroinflammation
Dihydroartemisinin 📋 32210783Dihydroartemisinin Ameliorates Learning and Memory in Alzheimer's Disease Through Promoting Autophagosome-Lysosome Fusion and Autolysosomal Degradation for Aβ Clearance
Docosapentaenoic Acid 📋✍ 33178186The Novel Omega-6 Fatty Acid Docosapentaenoic Acid Positively Modulates Brain Innate Immune Response for Resolving Neuroinflammation at Early and Late Stages of Humanized APOE-Based Alzheimer's Disease Models
Eclipta Alba 📋✍ 33145730Neuroprotective effects of hydro-alcoholic extract of Eclipta alba against 1-methyl-4-phenylpyridinium-induced in vitro and in vivo models of Parkinson's disease
Eleuthero 📋✍⛔38545117Acanthopanax senticosus improves cognitive impairment in Alzheimer's disease by promoting the phosphorylation of the MAPK signaling pathway
Equol 📋✍⛔32761299Equol, a Blood-Brain Barrier Permeable Gut Microbial Metabolite of Dietary Isoflavone Daidzein, Exhibits Neuroprotective Effects against Neurotoxins Induced Toxicity in Human Neuroblastoma SH-SY5Y Cells and Caenorhabditis elegans
Essential Fatty Acids 📋✍ 31255176Dietary fructose-induced gut dysbiosis promotes mouse hippocampal neuroinflammation: a benefit of short-chain fatty acids
Eucalyptus 📋✍⛔35298858Effects of a moisturizer containing pseudo-ceramide and a eucalyptus extract on sweating function in adult atopic dermatitis: a double-blind, randomized, controlled left-right comparison clinical trial
Fiber 📋✍⛔38142919Dietary fibre confers therapeutic effects in a preclinical model of Huntington's disease
Fig 📋 ⛔24938828Consumption of fig fruits grown in Oman can improve memory, anxiety, and learning skills in a transgenic mice model of Alzheimer's disease
Fufang Danshen 📋 29770796Suppression of MIF-induced neuronal apoptosis may underlie the therapeutic effects of effective components of Fufang Danshen in the treatment of Alzheimer's disease
Ginger Essential Oil 📋✍ 38106635The preventive effect of Zingiber officinale essential oil on demyelination of corpus callosum in a cuprizone rat model of multiple sclerosis
Ginkgetin 📋 29214278Ginkgetin Ameliorates Neuropathological Changes in APP/PS1 Transgenical Mice Model
Ginkgolic Acid 📋 31654699Ginkgolic acid promotes autophagy-dependent clearance of intracellular alpha-synuclein aggregates
Glycyrrhetinic Acid 📋 3743649118β-glycyrrhetinic acid ameliorates MPTP-induced neurotoxicity in mice through activation of microglial anti-inflammatory phenotype
Grape Seed Oil 📋 ⛔32665902Grape Seed Oil as a Natural Therapy in Male Rats with Alzheimer's Diseases
Hops 📋✍⛔35498911Discovery of 8-prenylnaringenin from hop ( Humulus lupulus L.) as a potent monoacylglycerol lipase inhibitor for treatments of neuroinflammation and Alzheimer's disease
Horse Chestnut 📋✍⛔32158393Escins Isolated from Aesculus chinensis Bge. Promote the Autophagic Degradation of Mutant Huntingtin and Inhibit its Induced Apoptosis in HT22 cells
Hypericin 📋 37183545Hypericin as a potential drug for treating Alzheimer's disease and type 2 diabetes with a view to drug repositioning
Isoquercitrin 📋 34047315The neuroprotective effects of isoquercitrin purified from apple pomace by high-speed countercurrent chromatography in the MPTP acute mouse model of Parkinson's disease
Isorhamnetin 📋 36160711Isorhamnetin Attenuated the Release of Interleukin-6 from β-Amyloid-Activated Microglia and Mitigated Interleukin-6-Mediated Neurotoxicity
Jujube 📋 ⛔35922734An aqueous macerate of Ziziphus jujuba reduces long-term spatial memory impairment in D-galactose treated rats: role of anti-inflammatory pathways
Kiwifruit 📋✍⛔26576196Antiamnesic Effect of Actinidia arguta Extract Intake in a Mouse Model of TMT-Induced Learning and Memory Dysfunction
Krill Oil 📋✍⛔36185487Antarctic krill oil exhibited synergistic effects with nobiletin and theanine in ameliorating memory and cognitive deficiency in SAMP8 mice: Applying the perspective of the sea-land combination to retard brain aging
L-Citrulline 📋✍⛔33940559Citrulline supplementation improves spatial memory in a murine model for Alzheimer's disease
L-Glutamine 📋✍⛔38489176Mendelian Randomization of Blood Metabolites Suggests Circulating Glutamine Protects Against Late-Onset Alzheimer's Disease
L-Leucine 📋✍⛔38382647Vcp overexpression and leucine supplementation extend lifespan and ameliorate neuromuscular junction phenotypes of a SOD1G93A-ALS mouse model
L-Lysine 📋✍⛔21127688Could Lysine Supplementation Prevent Alzheimer's Dementia? A Novel Hypothesis
Lemon Essential Oil 📋✍⛔33052945Aromatherapy improves cognitive dysfunction in senescence-accelerated mouse prone 8 by reducing the level of amyloid beta and tau phosphorylation
Lemon Verbena 📋 ⛔25617561Effects of dietary supplementation with lemon verbena extracts on serum inflammatory markers of multiple sclerosis patients
Lettuce 📋 ⛔35101010In vitro and in vivo evaluations of antioxidative, anti-Alzheimer, antidiabetic and anticancer potentials of hydroponically and soil grown Lactuca sativa
Limonin 📋 37536186Oral administration of Limonin (LM) exerts neuroprotective effects by inhibiting neuron autophagy and microglial activation in 6-OHDA-injected rats
Loquat 📋✍⛔21168467Neuroprotective effects of Eriobotrya japonica against β-amyloid-induced oxidative stress and memory impairment
Lupeol 📋 37447385A Triterpenoid Lupeol as an Antioxidant and Anti-Neuroinflammatory Agent: Impacts on Oxidative Stress in Alzheimer's Disease
Malvidin 📋 35874261Antiamnesic Potential of Malvidin on Aluminum Chloride Activated by the Free Radical Scavenging Property
Mandarin 📋 33808343A Flavonoid-Rich Extract of Mandarin Juice Counteracts 6-OHDA-Induced Oxidative Stress in SH-SY5Y Cells and Modulates Parkinson-Related Genes
Mango Leaf 📋 ⛔27537110Mango leaf extract improves central pathology and cognitive impairment in a type 2 diabetes mouse model
Marjoram 📋 ⛔37210483Origanum majorana L. protects against neuroinflammation-mediated cognitive impairment: a phyto-pharmacological study
Minerals 📋 37509049What Dietary Vitamins and Minerals Might Be Protective against Parkinson's Disease?
Mustard 📋 ⛔34856751Anti-Parkinson's evaluation of Brassica juncea leaf extract and underlying mechanism of its phytochemicals
Myrtle 📋✍⛔30553998Evaluation of the protective effect of Myrtus communis in scopolamine-induced Alzheimer model through cholinergic receptors
Neem 📋✍ 32477069Azadirachta indica A. Juss Ameliorates Mouse Hepatitis Virus-Induced Neuroinflammatory Demyelination by Modulating Cell-to-Cell Fusion in an Experimental Animal Model of Multiple Sclerosis
Oats 📋 ⛔34684684Oat Extract Avenanthramide-C Reverses Hippocampal Long-Term Potentiation Decline in Tg2576 Mice
Okra 📋 ⛔37358589Abelmoschus esculentus (Okra) Prevents Insulin Resistance and Restores Neuron Autophagy by Regulating Dipeptidyl Peptidase-4 and Thus Improving Hippocampal Function
Orange 📋 ⛔36678510Characterization of Orange Peel Extract and Its Potential Protective Effect against Aluminum Chloride-Induced Alzheimer's Disease
Orange Essential Oil 📋✍⛔33052945Aromatherapy improves cognitive dysfunction in senescence-accelerated mouse prone 8 by reducing the level of amyloid beta and tau phosphorylation
Oregano 📋✍⛔33298273Electrochemical screening of genoprotective and antioxidative effectiveness of Origanum vulgare L. and its functionality in the prevention of neurodegenerative disorders
Papaya 📋✍⛔36451797A comparative study of anti-aging effects of Carica papaya (pulp and seeds) on D-galactose-induced brain aging in albino rats
Parsnip 📋 ⛔32700246Xanthotoxin reverses Parkinson's disease-like symptoms in zebrafish larvae and mice models: a comparative study
Pau d'Arco 📋✍⛔35240121Antiparkinsonian activity of Tabebuia impetiginosa bark and biochemical analysis of dopamine in rat brain homogenates
Peppermint 📋✍⛔38625964Neuroprotective potential of Mentha piperita extract prevents motor dysfunctions in mouse model of Parkinson's disease through anti-oxidant capacities
Peppermint Essential Oil 📋✍⛔36986277Rosmarinus officinalis and Mentha piperita Oils Supplementation Enhances Memory in a Rat Model of Scopolamine-Induced Alzheimer's Disease-like Condition
Perilla 📋✍ 29092397Alpha-Linolenic Acid From Perilla Frutescens Var. Japonica Oil Protects Aβ-Induced Cognitive Impairment Through Regulation of APP Processing and Aβ Degradation
Phytosterols 📋 34830148Phytosterols: Potential Metabolic Modulators in Neurodegenerative Diseases
Pine Needle Essential Oil 📋✍⛔33655878Conifer Essential Oils Reversed Amyloid Beta1-42 Action by Modulating BDNF and ARC Expression in The Rat Hippocampus
Pine Nut 📋 ⛔37821052Ameliorative effects of pine nut peptide-zinc chelate (Korean pine) on a mouse model of Alzheimer's disease
Piperlongumine 📋 37188283Identification of Piperlongumine as Potent Inhibitor of Necroptosis
Pistachio 📋✍⛔32529399Amelioration of motor and non-motor deficits and increased striatal APoE levels highlight the beneficial role of pistachio supplementation in rotenone-induced rat model of PD
Pomegranate Seed extract 📋 ⛔35159404Punicic Acid and Its Role in the Prevention of Neurological Disorders: A Review
Poria Mushrooms 📋✍ 36374831Neuroprotective Effects of Poria cocos (Agaricomycetes) Essential Oil on Aβ1-40-Induced Learning and Memory Deficit in Rats
Postbiotics 📋 37934614Gut microbiome-targeted therapies for Alzheimer's disease
Protein 📋✍⛔38674911Analysis of the Association between Protein Intake and Disability-Adjusted Life Year Rates for Alzheimer's Disease in Japanese Aged over 60
Psyllium 📋✍⛔18474374The Hydrosoluble Fiber Plantago Ovata Husk Improves Levodopa (With Carbidopa) Bioavailability After Repeated Administration
Pumpkin Seed 📋✍⛔33759084Antiparkinsonian activity of Cucurbita pepo seeds along with possible underlying mechanism
Pyridoxal-5-Phosphate 📋✍⛔31987026An Evaluation of the Effects of Pyridoxal Phosphate in Chlorpromazineinduced Parkinsonism using Mice
Retinoic Acid 📋 36598970The immunomodulatory effects of all-trans retinoic acid and docosahexaenoic acid combination treatment on the expression of IL-2, IL-4, T-bet, and GATA3 genes in PBMCs of multiple sclerosis patients
Rosavin 📋 ⛔37758932Rosavin thwarts amyloid-β-induced macromolecular damages and neurotoxicity, exhibiting anti-Alzheimer's disease activity in Wister rat model
Rose 📋 37078068Effect of Rosa damascena Extract on Rat Model Alzheimer's Disease: A Histopathological, Behavioral, Enzyme Activities, and Oxidative Stress Study
Rosehip 📋✍⛔27563424Neuroprotective Effects of Herbal Extract (Rosa canina, Tanacetum vulgare and Urtica dioica) on Rat Model of Sporadic Alzheimer's Disease
Sage Essential Oil 📋 ⛔25778348Protective properties of Salvia lavandulifolia Vahl. essential oil against oxidative stress-induced neuronal injury
Scutellarein 📋 37239029A Multilevel Study of Eupatorin and Scutellarein as Anti-Amyloid Agents in Alzheimer's Disease
Scutellarin 📋 35964195Scutellarin Modulates the Microbiota-Gut-Brain Axis and Improves Cognitive Impairment in APP/PS1 Mice
Seafood 📋 36354985Marine Sources of DHA-Rich Phospholipids with Anti-Alzheimer Effect
Sesame 📋✍⛔37539928Neuroprotective effects of Sesamum indicum, sesamin and sesamolin against 6-OHDA-induced apoptosis in PC12 cells
Sesame Oil 📋 ⛔33049345Sesame oil mitigates memory impairment, oxidative stress, and neurodegeneration in a rat model of Alzheimer's disease. A pivotal role of NF-κB/p38MAPK/BDNF/PPAR-γ pathways
Shilajit 📋✍⛔37513872Scaling the Andean Shilajit: A Novel Neuroprotective Agent for Alzheimer's Disease
Shogaol 📋 373378306-Shogaol, an Active Ingredient of Ginger, Improves Intestinal and Brain Abnormalities in Proteus Mirabilis-Induced Parkinson's Disease Mouse Model
Sorghum 📋 ⛔34690742Potential of Sorghum Polyphenols to Prevent and Treat Alzheimer's Disease: A Review Article
Soy Protein 📋✍⛔36561237Ameliorating Effect of Standardized Extract From Textured Soy Protein ( Glycine max L.) on Memory Deficit and Learning Insufficiency in Scopolamine-induced Amnesia
Spearmint Essential Oil 📋✍⛔31772594Biological Properties and Bioactive Components of Mentha spicata L. Essential Oil: Focus on Potential Benefits in the Treatment of Obesity, Alzheimer's Disease, Dermatophytosis, and Drug-Resistant Infections
Star Fuit 📋 ⛔30196278Protective Effects of 2-Dodecyl-6-Methoxycyclohexa-2,5 -Diene-1,4-Dione Isolated from Averrhoa Carambola L. (Oxalidaceae) Roots on Neuron Apoptosis and Memory Deficits in Alzheimer's Disease
Sweet Potato 📋 ⛔35720655Effect of providing purple sweet potato water extract on tumor necrosis factor-α levels, protein 53 expression, glial fibrillary acidic protein expression, brain-derived neurotrophic factor levels, and spatial working memory in rats with d-galactose induction
Tamarind 📋 ⛔35481086The anti-Alzheimer potential of Tamarindus indica: an in vivo investigation supported by in vitro and in silico approaches
Tea Polyphenols 📋 29495349Neuroprotective Effects and Mechanisms of Tea Bioactive Components in Neurodegenerative Diseases
Theobromine 📋✍⛔27792010Theobromine-Induced Changes in A1 Purinergic Receptor Gene Expression and Distribution in a Rat Brain Alzheimer's Disease Model
Thyme 📋✍⛔30551467Beneficial effects of Thymus vulgaris extract in experimental autoimmune encephalomyelitis: Clinical, histological and cytokine alterations
Thyme Essential Oil 📋 ⛔38688382Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell
Trans-Resveratrol 📋 34402024Neuroprotective Effect of Trans-Resveratrol in Mild to Moderate Alzheimer Disease: A Randomized, Double-Blind Trial
Turkey Tail Mushrooms 📋 ⛔36289766Natural Compounds Such as Hericium erinaceus and Coriolus versicolor Modulate Neuroinflammation, Oxidative Stress and Lipoxin A4 Expression in Rotenone-Induced Parkinson's Disease in Mice
Vitamin K2 mk-7 📋✍ 37477796Vitamin K2 protects against aluminium chloride-mediated neurodegeneration
Whey Protein 📋✍⛔37414601Whey protein powder with milk fat globule membrane attenuates Alzheimer's disease pathology in 3×Tg-AD mice by modulating neuroinflammation through the peroxisome proliferator-activated receptor γ signaling pathway
White Mushrooms 📋 ⛔36291298White Button Mushroom ( Agaricus bisporus) Supplementation Ameliorates Spatial Memory Deficits and Plaque Formation in an Amyloid Precursor Protein Mouse Model of Alzheimer's Disease
White Tea 📋 ⛔21698507Neuroprotective effects of white tea against oxidative stress-induced toxicity in striatal cells
Wine 📋 ⛔26092624Olive Oil Phenols as Promising Multi-targeting Agents Against Alzheimer's Disease
Xylitol 📋✍⛔36154609Dietary xylitol supplement ameliorated AD related neuronal injury by regulating glucose metabolism relevant amino acids in mice